CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005022
UniProt Accession
Genbank Protein ID
 M55075 
Genbank Nucleotide ID
Protein Name
 Adenylate cyclase type 3 
Protein Synonyms/Alias
 ATP pyrophosphate-lyase 3; Adenylate cyclase type III; AC-III; Adenylate cyclase, olfactive type; Adenylyl cyclase 3; AC3 
Gene Name
 Adcy3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
878KIEVHDQKERVYEMRubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
 Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration. 
Sequence Annotation
 METAL 324 324 Magnesium 1 (By similarity).
 METAL 324 324 Magnesium 2 (By similarity).
 METAL 325 325 Magnesium 2; via carbonyl oxygen (By
 METAL 368 368 Magnesium 1 (By similarity).
 METAL 368 368 Magnesium 2 (By similarity).
 CARBOHYD 734 734 N-linked (GlcNAc...) (Potential).  
Keyword
 ATP-binding; Calmodulin-binding; cAMP biosynthesis; Complete proteome; Glycoprotein; Lyase; Magnesium; Membrane; Metal-binding; Nucleotide-binding; Olfaction; Reference proteome; Repeat; Sensory transduction; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1144 AA 
Protein Sequence
MTEDQGFSDP EYSAEYSAEY SVSLPSDPDR GVGRTHEISV RNSGSCLCLP RFMRLTFVPE 60
SLENLYQTYF KRQRHETLLV LVVFAALFDC YVVVMCAVVF SSDKLAPLMV AGVGLVLDII 120
LFVLCKKGLL PDRVSRKVVP YLLWLLITAQ IFSYLGLNFS RAHAASDTVG WQAFFVFSFF 180
ITLPLSLSPI VIISVVSCVV HTLVLGVTVA QQQQDELEGM QLLREILANV FLYLCAIIVG 240
IMSYYMADRK HRKAFLEARQ SLEVKMNLEE QSQQQENLML SILPKHVADE MLKDMKKDES 300
QKDQQQFNTM YMYRHENVSI LFADIVGFTQ LSSACSAQEL VKLLNELFAR FDKLAAKYHQ 360
LRIKILGDCY YCICGLPDYR EDHAVCSILM GLAMVEAISY VREKTKTGVD MRVGVHTGTV 420
LGGVLGQKRW QYDVWSTDVT VANKMEAGGI PGRVHISQST MDCLKGEFDV EPGDGGSRCD 480
YLDEKGIETY LIIASKPEVK KTAQNGLNGS ALPNGAPASK PSSPALIETK EPNGSAHASG 540
STSEEAEEQE AQADNPSFPN PRRRLRLQDL ADRVVDASED EHELNQLLNE ALLERESAQV 600
VKKRNTFLLT MRFMDPEMET RYSVEKEKQS GAAFSCSCVV LFCTAMVEIL IDPWLMTNYV 660
TFVVGEVLLL ILTICSMAAI FPRAFPKKLV AFSSWIDRTR WARNTWAMLA IFILVMANVV 720
DMLSCLQYYM GPYNVTTGIE LDGGCMENPK YYNYVAVLSL IATIMLVQVS HMVKLTLMLL 780
VTGAVTAINL YAWCPVFDEY DHKRFQEKDS PMVALEKMQV LSTPGLNGTD SRLPLVPSKY 840
SMTVMMFVMM LSFYYFSRHV EKLARTLFLW KIEVHDQKER VYEMRRWNEA LVTNMLPEHV 900
ARHFLGSKKR DEELYSQSYD EIGVMFASLP NFADFYTEES INNGGIECLR FLNEIISDFD 960
SLLDNPKFRV ITKIKTIGST YMAASGVTPD VNTNGFTSSS KEEKSDKERW QHLADLADFA 1020
LAMKDTLTNI NNQSFNNFML RIGMNKGGVL AGVIGARKPH YDIWGNTVNV ASRMESTGVM 1080
GNIQVVEETQ VILREYGFRF VRRGPIFVKG KGELLTFFLK GRDRPAAFPN GSSVTLPHQV 1140
VDNP 1144 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0045121; C:membrane raft; IDA:RGD.
 GO:0005634; C:nucleus; IDA:RGD.
 GO:0005886; C:plasma membrane; IDA:RGD.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0008294; F:calcium- and calmodulin-responsive adenylate cyclase activity; IDA:RGD.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0007143; P:female meiosis; IEP:RGD.
 GO:0035556; P:intracellular signal transduction; IDA:RGD.
 GO:0007608; P:sensory perception of smell; IDA:RGD. 
Interpro
 IPR001054; A/G_cyclase.
 IPR018297; A/G_cyclase_CS. 
Pfam
 PF00211; Guanylate_cyc 
SMART
 SM00044; CYCc 
PROSITE
 PS00452; GUANYLATE_CYCLASE_1
 PS50125; GUANYLATE_CYCLASE_2 
PRINTS