| Tag | Content |
|---|
| CPLM ID | CPLM-017244 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Importin-11 |
Protein Synonyms/Alias | Imp11; Ran-binding protein 11; RanBP11 |
Gene Name | Ipo11 |
Gene Synonyms/Alias | Ranbp11 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 216 | ERTLLSLKVLRKLTV | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of RPL12, and of UBE2E3 (By similarity). |
Sequence Annotation | DOMAIN 28 100 Importin N-terminal.
REPEAT 123 160 HEAT 1.
REPEAT 283 317 HEAT 2.
REPEAT 318 356 HEAT 3.
REPEAT 422 459 HEAT 4.
REPEAT 473 509 HEAT 5.
REPEAT 511 548 HEAT 6.
REPEAT 555 593 HEAT 7.
REPEAT 600 636 HEAT 8.
REPEAT 640 677 HEAT 9.
REPEAT 683 720 HEAT 10.
REPEAT 731 773 HEAT 11.
REPEAT 819 849 HEAT 12.
REPEAT 850 887 HEAT 13.
REPEAT 957 974 HEAT 14.
MOD_RES 1 1 N-acetylmethionine (By similarity). |
Keyword | Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Nucleus; Protein transport; Reference proteome; Repeat; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 975 AA |
Protein Sequence | MDLNSASSVV LQVLTQATSQ DTAVLKPAEE QLKQWETQPG FYSVLLNIFT NHTLDINVRW 60
LAVLYFKHGI DRYWRRVAPH ALSEEEKSTL RAGLITNFNE PINQIATQIA VLIAKVARLD 120
CPRQWPELIP TLVESVKVQD DLRQHRALLT FYHVTKTLAS KRLAADRKLF YDLASGIYNF 180
ACSLWNHHTD TFLQHVSSGN EAAVLSSLER TLLSLKVLRK LTVNGFVEPH KNMEVMGFLH 240
GIFERLKQFL ECSRSIGTDN VCRDRLEKTI ILFTKVLLDF LDQHPISFTP LIQRSLEFSV 300
SYVFTEVGEG VTFERFIVQC MNLIKMIVKN YAYKPSKNFE DSSPETLEAH KIKMAFFTYP 360
TLTEICRRLV SHYFLLTEEE LTMWEEDPEG FTVEETGGDS WKYSLRPCTE VLFIDIFHEY 420
NQTLTPVLLE MMQTLEGPTN VEDMNALLIK DAVYNAVGLA AFELFDSVDF DQWFKTQLLP 480
ELQVSHNRYK PLRRRVIWLI GQWISVKFKS DLRPMLYEAI CNLLQDQDLV VRIETATTLK 540
LTVDDFEFRT DQFLPYLETM FTLLFQLLQQ VTECDTKMHV LHVLSCVIER VNVQIRPYVG 600
CLVQYLPLLW KQSEEHNMLR CAILTTLIHL VQGLGADSKN LYPFLLPVIQ LSTDVSQPPH 660
VYLLEDGLEL WLVTLENSPC VTPELLRIFQ NMSPLLELSS ENLRTCFKII NGYIFLSSTE 720
FLQTYAAGLC QSFYELLPEI TTEGQVQVLK VVENALKVNP VLGPQMFQRI LPCVFRGVIE 780
GERYPVVMSI YLAVMGRVLL QNTSFFSSLL NEMGHEFNQE MDQLLGNVIE MWVDRMDNIT 840
QPERKKLSAL ALLSLLPSDN SVIQDKFCGI INISVEALHD VMTEDPETRT YKDCMLMSQH 900
EEPKVTEDEE PPTEQDKRKK MLALKDPVHT VSLQQFIYEK LKAQQEILGE QGFQSLMETV 960
DTEIVTQLQE FLQGF 975 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0005643; C:nuclear pore; IEA:InterPro. GO:0008565; F:protein transporter activity; IDA:MGI. GO:0006610; P:ribosomal protein import into nucleus; IDA:MGI. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |