CPLM-014636

Genbank Nucleotide ID

Histone H2B type 1-H

Protein Synonyms/Alias

Mus musculus (Mouse)

Position	Peptide	Type	References
6	**MPEPAKSAPAPKK	acetylation	[1]
12	AKSAPAPKKGSKKAL	acetylation	[1, 2, 3]
13	KSAPAPKKGSKKALT	acetylation	[1, 2, 3]
16	PAPKKGSKKALTKAQ	acetylation	[1, 2, 3, 4]
17	APKKGSKKALTKAQK	acetylation	[1, 2, 3, 4, 5]
21	GSKKALTKAQKKDGK	acetylation	[2, 3, 4, 5]
24	KALTKAQKKDGKKRK	acetylation	[4]
109	LLPGELAKHAVSEGT	acetylation	[1]
121	EGTKAVTKYTSSK**	acetylation	[1]

[1] Comprehensive mapping of post-translational modifications on synaptic, nuclear, and histone proteins in the adult mouse brain.
Tweedie-Cullen RY, Reck JM, Mansuy IM.
J Proteome Res. 2009 Nov;8(11):4966-82. [PMID: 19737024]
[2] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
Simon GM, Cheng J, Gordon JI.
Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
[3] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
[4] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
[5] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]

Functional Description

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

MOD_RES 2 2 N-acetylproline (By similarity).
MOD_RES 6 6 N6-acetyllysine; alternate (By
MOD_RES 6 6 N6-crotonyl-L-lysine; alternate.
MOD_RES 12 12 N6-acetyllysine; alternate (By
MOD_RES 12 12 N6-crotonyl-L-lysine; alternate.
MOD_RES 13 13 N6-acetyllysine; alternate (By
MOD_RES 13 13 N6-crotonyl-L-lysine; alternate.
MOD_RES 15 15 Phosphoserine; by STK4/MST1.
MOD_RES 16 16 N6-acetyllysine; alternate (By
MOD_RES 16 16 N6-crotonyl-L-lysine; alternate.
MOD_RES 17 17 N6-acetyllysine; alternate (By
MOD_RES 17 17 N6-crotonyl-L-lysine; alternate.
MOD_RES 21 21 N6-acetyllysine; alternate (By
MOD_RES 21 21 N6-crotonyl-L-lysine; alternate.
MOD_RES 24 24 N6-acetyllysine; alternate (By
MOD_RES 24 24 N6-crotonyl-L-lysine; alternate.
MOD_RES 35 35 N6-crotonyl-L-lysine; alternate.
MOD_RES 37 37 Phosphoserine; by AMPK.
MOD_RES 43 43 Phosphotyrosine (By similarity).
MOD_RES 47 47 N6-methyllysine (By similarity).
MOD_RES 58 58 N6,N6-dimethyllysine (By similarity).
MOD_RES 109 109 N6-methyllysine (By similarity).
MOD_RES 113 113 Phosphoserine; alternate (By similarity).
CARBOHYD 113 113 O-linked (GlcNAc...); alternate (By
CROSSLNK 35 35 Glycyl lysine isopeptide (Lys-Gly)
CROSSLNK 121 121 Glycyl lysine isopeptide (Lys-Gly)

Acetylation; Chromosome; Complete proteome; DNA-binding; Glycoprotein; Isopeptide bond; Methylation; Nucleosome core; Nucleus; Phosphoprotein; Reference proteome; Ubl conjugation.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
GO:0006334; P:nucleosome assembly; IEA:InterPro.

IPR009072; Histone-fold.
IPR007125; Histone_core_D.
IPR000558; Histone_H2B.

PS00357; HISTONE_H2B

PR00621; HISTONEH2B.