CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-034424
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 6-phosphogluconolactonase 
Protein Synonyms/Alias
 6-phosphogluconolactonase, isoform CRA_b 
Gene Name
 Pgls 
Gene Synonyms/Alias
 mCG_10369 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
97APISDSPKPPPQRVTacetylation[1, 2, 3]
136LKRILEDKEGTLPAAacetylation[2]
136LKRILEDKEGTLPAAubiquitination[4]
170LLSVPFEKHSTL***acetylation[2]
170LLSVPFEKHSTL***ubiquitination[4]
Reference
 [1] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [4] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 174 AA 
Protein Sequence
MSIQVQPDGP PSPTHLLSKL PIPDSQVLTI NPALPVEDAA EDYARKLRQA LQGDAVPVFD 60
LLILGVGPDG HTCSLFPDHP LLQEREKIVA PISDSPKPPP QRVTLTLPVL NAAQSIIFVA 120
TGEGKAAVLK RILEDKEGTL PAALVQPRTG ALCWFLDEAA ARLLSVPFEK HSTL 174 
Gene Ontology
 GO:0017057; F:6-phosphogluconolactonase activity; IEA:InterPro.
 GO:0006098; P:pentose-phosphate shunt; IEA:InterPro. 
Interpro
 IPR005900; 6-phosphogluconolactonase_DevB.
 IPR006148; Glc/Gal-6P_isomerase. 
Pfam
 PF01182; Glucosamine_iso 
SMART
  
PROSITE
  
PRINTS