UniProt Accession

 CXA5_MOUSE; Q01231 

Genbank Protein ID

 X61675; BC053054 

Genbank Nucleotide ID

 CAA43850.1; AAH53054.1 

Protein Name

 Gap junction alpha-5 protein 

Protein Synonyms/Alias

 Connexin-40; Cx40 

Gene Name

 Gja5 

Gene Synonyms/Alias

 Cxn-40 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
130	YEYPVAEKAELSCWK	ubiquitination	[1]
278	LKNSSGEKFFSDFSN	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. 

Sequence Annotation

  

Keyword

 Cell junction; Cell membrane; Complete proteome; Gap junction; Membrane; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 358 AA 

Protein Sequence

Gene Ontology

 GO:0005922; C:connexon complex; IEA:Compara.
 GO:0005921; C:gap junction; IDA:MGI.
 GO:0005887; C:integral to plasma membrane; IEA:Compara.
 GO:0014704; C:intercalated disc; IEA:Compara.
 GO:0086077; F:gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling; IEA:Compara.
 GO:0055077; F:gap junction hemi-channel activity; IEA:Compara.
 GO:0001525; P:angiogenesis; IEA:Compara.
 GO:0048844; P:artery morphogenesis; IMP:BHF-UCL.
 GO:0060413; P:atrial septum morphogenesis; IMP:MGI.
 GO:0003294; P:atrial ventricular junction remodeling; IMP:MGI.
 GO:0086067; P:AV node cell to bundle of His cell communication; IMP:MGI.
 GO:0086069; P:bundle of His cell to Purkinje myocyte communication; IEA:Compara.
 GO:0003161; P:cardiac conduction system development; IMP:MGI.
 GO:0086064; P:cell communication by electrical coupling involved in cardiac conduction; IMP:MGI.
 GO:0035050; P:embryonic heart tube development; IMP:MGI.
 GO:0030326; P:embryonic limb morphogenesis; IMP:MGI.
 GO:0035922; P:foramen ovale closure; IMP:MGI.
 GO:0016264; P:gap junction assembly; IEA:Compara.
 GO:0003174; P:mitral valve development; IEA:Compara.
 GO:0003151; P:outflow tract morphogenesis; IEA:Compara.
 GO:0003193; P:pulmonary valve formation; IEA:Compara.
 GO:0086014; P:regulation of atrial cardiac muscle cell action potential; IEA:Compara.
 GO:0060371; P:regulation of atrial cardiac muscle cell membrane depolarization; IMP:MGI.
 GO:0086091; P:regulation of heart rate by cardiac conduction; IMP:MGI.
 GO:1900825; P:regulation of membrane depolarization involved in regulation of cardiac muscle cell action potential; IMP:MGI.
 GO:1900133; P:regulation of renin secretion into blood stream; IMP:MGI.
 GO:0086015; P:regulation of SA node cell action potential; IMP:MGI.
 GO:0042312; P:regulation of vasodilation; IMP:MGI.
 GO:0086005; P:regulation of ventricular cardiac muscle cell action potential; IMP:MGI.
 GO:0060373; P:regulation of ventricular cardiac muscle cell membrane depolarization; IMP:MGI.
 GO:0060307; P:regulation of ventricular cardiac muscle cell membrane repolarization; IMP:MGI.
 GO:0003071; P:renal system process involved in regulation of systemic arterial blood pressure; IMP:MGI.
 GO:0003284; P:septum primum development; IMP:MGI.
 GO:0001501; P:skeletal system development; IMP:MGI.
 GO:0060412; P:ventricular septum morphogenesis; IMP:MGI. 

Interpro

 IPR000500; Connexin.
 IPR002264; Connexin40.
 IPR019570; Connexin_CCC.
 IPR017990; Connexin_CS.
 IPR013092; Connexin_N. 

Pfam

 PF00029; Connexin
 PF10582; Connexin_CCC 

SMART

 SM00037; CNX
 SM01089; Connexin_CCC 

PROSITE

 PS00407; CONNEXINS_1
 PS00408; CONNEXINS_2 

PRINTS

 PR00206; CONNEXIN.
 PR01135; CONNEXINA5.