| Tag | Content |
|---|
| CPLM ID | CPLM-002192 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Anion exchange protein 2 |
Protein Synonyms/Alias | AE 2; Anion exchanger 2; Non-erythroid band 3-like protein; BND3L; Solute carrier family 4 member 2 |
Gene Name | SLC4A2 |
Gene Synonyms/Alias | AE2; EPB3L1; HKB3; MPB3L |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 320 | LNELLLDKNQEPQWR | ubiquitination | [1] | | 334 | RETARWIKFEEDVEE | ubiquitination | [1] | | 644 | EPKSAQDKALLQMVE | ubiquitination | [1] | | 879 | AGQSGQGKPRGQPNT | ubiquitination | [1] | | 961 | FSVTAPEKRGWVINP | ubiquitination | [1] | | 1059 | NALTVMSKAVAPGDK | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Plasma membrane anion exchange protein of wide distribution. |
Sequence Annotation | REGION 708 1241 Membrane (anion exchange).
MOD_RES 113 113 Phosphoserine.
MOD_RES 132 132 Phosphoserine.
MOD_RES 144 144 Phosphoserine.
MOD_RES 173 173 Phosphoserine.
MOD_RES 183 183 Phosphothreonine.
MOD_RES 443 443 Phosphoserine.
LIPID 1173 1173 S-palmitoyl cysteine (By similarity).
CARBOHYD 859 859 N-linked (GlcNAc...) (Potential).
CARBOHYD 868 868 N-linked (GlcNAc...) (Potential).
CARBOHYD 882 882 N-linked (GlcNAc...) (Potential). |
Keyword | Alternative splicing; Anion exchange; Antiport; Complete proteome; Glycoprotein; Ion transport; Lipoprotein; Membrane; Palmitate; Phosphoprotein; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1241 AA |
Protein Sequence | MTQPEPESLG PGTPGFPEQE EDELHRTLGV ERFEEILQEA GSRGGEEPGR SYGEEDFEYH 60
RQSSHHIHHP LSTHLPPDAR RRKTPQGPGR KPRRRPGASP TGETPTIEEG EEDEDEASEA 120
EGARALTQPS PVSTPSSVQF FLQEDDSADR KAERTSPSSP APLPHQEATP RASKGAQAGT 180
QVEEAEAEAV AVASGTAGGD DGGASGRPLP KAQPGHRSYN LQERRRIGSM TGAEQALLPR 240
VPTDEIEAQT LATADLDLMK SHRFEDVPGV RRHLVRKNAK GSTQSGREGR EPGPTPRARP 300
RAPHKPHEVF VELNELLLDK NQEPQWRETA RWIKFEEDVE EETERWGKPH VASLSFRSLL 360
ELRRTLAHGA VLLDLDQQTL PGVAHQVVEQ MVISDQIKAE DRANVLRALL LKHSHPSDEK 420
DFSFPRNISA GSLGSLLGHH HGQGAESDPH VTEPLMGGVP ETRLEVERER ELPPPAPPAG 480
ITRSKSKHEL KLLEKIPENA EATVVLVGCV EFLSRPTMAF VRLREAVELD AVLEVPVPVR 540
FLFLLLGPSS ANMDYHEIGR SISTLMSDKQ FHEAAYLADE REDLLTAINA FLDCSVVLPP 600
SEVQGEELLR SVAHFQRQML KKREEQGRLL PTGAGLEPKS AQDKALLQMV EAAGAAEDDP 660
LRRTGRPFGG LIRDVRRRYP HYLSDFRDAL DPQCLAAVIF IYFAALSPAI TFGGLLGEKT 720
QDLIGVSELI MSTALQGVVF CLLGAQPLLV IGFSGPLLVF EEAFFSFCSS NHLEYLVGRV 780
WIGFWLVFLA LLMVALEGSF LVRFVSRFTQ EIFAFLISLI FIYETFYKLV KIFQEHPLHG 840
CSASNSSEVD GGENMTWAGA RPTLGPGNRS LAGQSGQGKP RGQPNTALLS LVLMAGTFFI 900
AFFLRKFKNS RFFPGRIRRV IGDFGVPIAI LIMVLVDYSI EDTYTQKLSV PSGFSVTAPE 960
KRGWVINPLG EKSPFPVWMM VASLLPAILV FILIFMETQI TTLIISKKER MLQKGSGFHL 1020
DLLLIVAMGG ICALFGLPWL AAATVRSVTH ANALTVMSKA VAPGDKPKIQ EVKEQRVTGL 1080
LVALLVGLSI VIGDLLRQIP LAVLFGIFLY MGVTSLNGIQ FYERLHLLLM PPKHHPDVTY 1140
VKKVRTLRMH LFTALQLLCL ALLWAVMSTA ASLAFPFILI LTVPLRMVVL TRIFTDREMK 1200
CLDANEAEPV FDEREGVDEY NEMPMPV 1227 |
Gene Ontology | GO:0016323; C:basolateral plasma membrane; IEA:Compara. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005886; C:plasma membrane; TAS:Reactome. GO:0008509; F:anion transmembrane transporter activity; TAS:ProtInc. GO:0015108; F:chloride transmembrane transporter activity; IEA:Compara. GO:0005452; F:inorganic anion exchanger activity; IEA:InterPro. GO:0015701; P:bicarbonate transport; TAS:Reactome. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |