CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022810
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Neurochondrin 
Protein Synonyms/Alias
  
Gene Name
 NCDN 
Gene Synonyms/Alias
 KIAA0607 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
66LLVTKAVKAGDIDAKubiquitination[1]
94PNRLLTTKEAPDGCPubiquitination[1]
274LARILGSKLSSWQRNubiquitination[1, 2]
285WQRNPALKLAARLAHubiquitination[1]
485GPREILIKEGAPSLLubiquitination[3]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 
Functional Description
 Probably involved in signal transduction, in the nervous system, via increasing cell surface localization of GRM5 and positively regulating its signaling (By similarity). Required for the spatial learning process. Acts as a negative regulator of Ca(2+)-calmodulin-dependent protein kinase 2 (CaMK2) phosphorylation. May play a role in modulating melanin- concentrating hormone-mediated functions via its interaction with MCHR1 that interferes with G protein-coupled signal transduction. May be involved in bone metabolism. May also be involved in neurite outgrowth. 
Sequence Annotation
 MOD_RES 2 2 N-acetylserine.  
Keyword
 Acetylation; Alternative splicing; Cell projection; Complete proteome; Cytoplasm; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 729 AA 
Protein Sequence
ALGEDFAARG RSLLGKASIM ASDCEPALNQ AEGRNPTLER YLGALREAKN DSEQFAALLL 60
VTKAVKAGDI DAKTRRRIFD AVGFTFPNRL LTTKEAPDGC PDHVLRALGV ALLACFCSDP 120
ELAAHPQVLN KIPILSTFLT ARGDPDDAAR RSMIDDTYQC LTAVAGTPRG PRHLIAGGTV 180
SALCQAYLGH GYGFDQALAL LVGLLAAAET QCWKEAEPDL LAVLRGLSED FQKAEDASKF 240
ELCQLLPLFL PPTTVPPECY RDLQAGLARI LGSKLSSWQR NPALKLAARL AHACGSDWIP 300
AGSSGSKFLA LLVNLACVEV RLALEETGTE VKEDVVTACY ALMELGIQEC TRCEQSLLKE 360
PQKVQLVSVM KEAIGAVIHY LLQVGSEKQK EPFVFASVRI LGAWLAEETS SLRKEVCQLL 420
PFLVRYAKTL YEEAEEANDL SQQVANLAIS PTTPGPTWPG DALRLLLPGW CHLTVEDGPR 480
EILIKEGAPS LLCKYFLQQW ELTSPGHDTS VLPDSVEIGL QTCCHIFLNL VVTAPGLIKR 540
DACFTSLMNT LMTSLPALVQ QQGRLLLAAN VATLGLLMAR LLSTSPALQG TPASRGFFAA 600
AILFLSQSHV ARATPGSDQA VLALSPEYEG IWADLQELWF LGMQAFTGCV PLLPWLAPAA 660
LRSRWPQELL QLLGSVSPNS VKPEMVAAYQ GVLVELARAN RLCREAMRLQ AGEETASHYR 720
MAALEQCLSE P 731 
Gene Ontology
 GO:0005829; C:cytosol; ISS:UniProtKB.
 GO:0030425; C:dendrite; ISS:UniProtKB.
 GO:0043025; C:neuronal cell body; ISS:UniProtKB.
 GO:0045453; P:bone resorption; IEA:Compara.
 GO:0031175; P:neuron projection development; ISS:UniProtKB.
 GO:0048168; P:regulation of neuronal synaptic plasticity; IEA:Compara. 
Interpro
 IPR008709; Neurochondrin. 
Pfam
  
SMART
  
PROSITE
  
PRINTS