UniProt Accession

 LITAF_HUMAN; Q99732; D3DUG1; G5E9K0; Q05DW0; Q9C0L6 

Genbank Protein ID

 AF010312; U77396; AB034747; AK095955; BX537543; AC007616; AC099489; CH471112; CH471112; CH471112; CH471112; BC000053; BC008309; BC016491; BC039840; BC046154; BC096063; BC096065; BC096066; BC101401; BC101402; BC101969 

Genbank Nucleotide ID

 AAC39530.1; AAB36550.1; BAB32547.1; CAD97778.1; EAW85150.1; EAW85151.1; EAW85152.1; EAW85153.1; AAH00053.1; AAH08309.1; AAH16491.1; AAH39840.1; AAH46154.1; AAH96063.1; AAH96065.1; AAH96066.1; AAI01402.1; AAI01403.1; AAI01970.1 

Protein Name

 Lipopolysaccharide-induced tumor necrosis factor-alpha factor 

Protein Synonyms/Alias

 LPS-induced TNF-alpha factor; Small integral membrane protein of lysosome/late endosome; p53-induced gene 7 protein 

Gene Name

 LITAF 

Gene Synonyms/Alias

 PIG7; SIMPLE 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
159	RALLGTYKRL*****	ubiquitination	[1, 2, 3]

Reference

 [1] Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level.
 Danielsen JM, Sylvestersen KB, Bekker-Jensen S, Szklarczyk D, Poulsen JW, Horn H, Jensen LJ, Mailand N, Nielsen ML.
 Mol Cell Proteomics. 2011 Mar;10(3):M110.003590. [PMID: 21139048]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Probable role in regulating transcription of specific genes. May regulate through NFKB1 the expression of the CCL2/MCP-1 chemokine. May play a role in tumor necrosis factor alpha (TNF- alpha) gene expression. 

Sequence Annotation

 MOTIF 20 23 WW-binding.  

Keyword

 Alternative splicing; Apoptosis; Charcot-Marie-Tooth disease; Complete proteome; Disease mutation; Lysosome; Membrane; Neuropathy; Polymorphism; Proto-oncogene; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 161 AA 

Protein Sequence

Gene Ontology

 GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
 GO:0005765; C:lysosomal membrane; IDA:MGI.
 GO:0005886; C:plasma membrane; IMP:UniProtKB.
 GO:0004871; F:signal transducer activity; IMP:UniProtKB.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
 GO:0071222; P:cellular response to lipopolysaccharide; IEA:Compara.
 GO:0042347; P:negative regulation of NF-kappaB import into nucleus; IEA:Compara.
 GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; IMP:UniProtKB.
 GO:0001817; P:regulation of cytokine production; IEA:Compara.
 GO:0006357; P:regulation of transcription from RNA polymerase II promoter; TAS:ProtInc.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR006629; LITAF. 

Pfam

 PF10601; zf-LITAF-like 

SMART

 SM00714; LITAF 

PROSITE

  

PRINTS