| Tag | Content |
|---|
| CPLM ID | CPLM-022763 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Pre-mRNA-processing factor 40 homolog A |
Protein Synonyms/Alias | Formin-binding protein 11; FBP-11; Formin-binding protein 3 |
Gene Name | Prpf40a |
Gene Synonyms/Alias | Fbp11; Fnbp3 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 714 | TLDAGNIKLAFNSLL | ubiquitination | [1] | | 723 | AFNSLLEKAEARERE | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Binds to WASL/N-WASP and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. May play a role in cytokinesis. May be involved in pre-mRNA splicing. |
Sequence Annotation | DOMAIN 140 173 WW 1.
DOMAIN 181 214 WW 2.
DOMAIN 389 443 FF 1.
DOMAIN 456 510 FF 2.
DOMAIN 523 583 FF 3.
DOMAIN 603 663 FF 4.
DOMAIN 668 723 FF 5.
DOMAIN 738 795 FF 6.
MOD_RES 36 36 Phosphoserine.
MOD_RES 151 151 Phosphoserine (By similarity).
MOD_RES 196 196 N6-acetyllysine (By similarity).
MOD_RES 369 369 Phosphothreonine (By similarity).
MOD_RES 824 824 Phosphoserine.
MOD_RES 826 826 Phosphoserine.
MOD_RES 828 828 Phosphoserine.
MOD_RES 830 830 Phosphoserine.
MOD_RES 879 879 Phosphoserine.
MOD_RES 881 881 Phosphoserine.
MOD_RES 884 884 Phosphoserine.
MOD_RES 928 928 Phosphothreonine.
MOD_RES 929 929 Phosphoserine.
MOD_RES 931 931 Phosphoserine.
MOD_RES 934 934 Phosphoserine. |
Keyword | Acetylation; Alternative splicing; Complete proteome; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Reference proteome; Repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 953 AA |
Protein Sequence | MRPGTGAERG GLMVSEMESQ PPSRGPGDGE RRLSGSNLCS SSWVSADGFL RRRPSMGHPG 60
MHYAPMGMHP MGQRANMPPV PHGMMPQMMP PMGGPPMGQM PGMMSSVMSG MMMSHMSQAS 120
MQPALPPGVN SMDVAAGAAS GAKSMWTEHK SPDGRTYYYN TETKQSTWEK PDDLKTPAEQ 180
LLSKCPWKEY KSDSGKPYYY NSQTKESRWA KPKELEDLEG YQNTIVAGGL ITKSNLHAMI 240
KAEESSKQEE CTTASTAPVP TTEIPTTMST MAAAEAAAAV VAAAAAAAAA ANANTSTTPT 300
NTVGSVPVAP EPEVTSIVAT AVDNENTVTV STEEQAQLAN TTAIQDLSGD ISSNTGEEPA 360
KQETVSDFTP KKEEEESQPA KKTYTWNTKE EAKQAFKELL KEKRVPSNAS WEQAMKMIIN 420
DPRYSALAKL SEKKQAFNAY KVQTEKEEKE EARSKYKEAK ESFQRFLENH EKMTSTTRYK 480
KAEQMFGEME VWNAISERDR LEIYEDVLFF LSKKEKEQAK QLRKRNWEAL KNILDNMANV 540
TYSTTWSEAQ QYLMDNPTFA EDEELQNMDK EDALICFEEH IRALEKEEEE EKQKTLLRER 600
RRQRKNRESF QIFLDELHEH GQLHSMSSWM ELYPTISSDI RFTNMLGQPG STALDLFKFY 660
VEDLKARYHD EKKIIKDILK DKGFVVEVNT TFEDFVAIIS STKRSTTLDA GNIKLAFNSL 720
LEKAEARERE REKEEARKMK RKESAFKSML KQATPPIELD AVWEDIRERF VKEPAFEDIT 780
LESERKRIFK DFMHVLEHEC QHHHSKNKKH SKKSKKHHRK RSRSRSGSES DDDDSHSKKK 840
RQRSESHSAS ERSSSAESER SYKKSKKHKK KSKKRRHKSD SPESDTEREK DKKEKDRDSE 900
KDRSRQRSES KHKSPKKKTG KDSGNWDTSG SELSEGELEK RRRTLLEQLD DDQ 953 |
Gene Ontology | GO:0016363; C:nuclear matrix; IDA:UniProtKB. GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell. GO:0070064; F:proline-rich region binding; IDA:MGI. GO:0016477; P:cell migration; ISS:UniProtKB. GO:0007010; P:cytoskeleton organization; ISS:UniProtKB. GO:0006397; P:mRNA processing; IEA:UniProtKB-KW. GO:0008360; P:regulation of cell shape; ISS:UniProtKB. GO:0032465; P:regulation of cytokinesis; ISS:UniProtKB. GO:0008380; P:RNA splicing; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |