UniProt Accession

 TCTP_MOUSE; P63028; P14701; Q3TMT0; Q3TWS8; Q3TWX0; Q3UAG7; Q569M9 

Genbank Protein ID

 X06407; AY186881; AK149695; AK150300; AK150500; AK150858; AK151059; AK151266; AK151375; AK151894; AK152690; AK152808; AK159516; AK159565; AK165736; AK166584; AK167413; AK167936; AK168151; AK169730; BC092381 

Genbank Nucleotide ID

 CAA29697.1; AAP23875.1; BAE29032.1; BAE29452.1; BAE29613.1; BAE29913.1; BAE30076.1; BAE30253.1; BAE30347.1; BAE30778.1; BAE31421.1; BAE31513.1; BAE35146.1; BAE35188.1; BAE38361.1; BAE38873.1; BAE39502.1; BAE39940.1; BAE40116.1; BAE41334.1; AAH92381.1 

Protein Name

 Translationally-controlled tumor protein 

Protein Synonyms/Alias

 TCTP; 21 kDa polypeptide; p21; p23 

Gene Name

 Tpt1 

Gene Synonyms/Alias

 Trt 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
19	ELFSDIYKIREIADG	acetylation	[1]
19	ELFSDIYKIREIADG	ubiquitination	[2]
93	EAYKKYIKDYMKSLK	acetylation	[3]
112	EQKPERVKPFMTGAA	ubiquitination	[2]
164	TPFMIFFKDGLEMEK	ubiquitination	[2]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 

Functional Description

 Involved in calcium binding and microtubule stabilization (By similarity). 

Sequence Annotation

 MOD_RES 46 46 Phosphoserine; by PLK1 (By similarity).
 MOD_RES 53 53 Phosphoserine (By similarity).
 MOD_RES 64 64 Phosphoserine; by PLK1 (By similarity).  

Keyword

 Calcium; Complete proteome; Cytoplasm; Direct protein sequencing; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 172 AA 

Protein Sequence

Gene Ontology

 GO:0005615; C:extracellular space; ISO:MGI.
 GO:0005771; C:multivesicular body; ISO:MGI.
 GO:0005654; C:nucleoplasm; IDA:BHF-UCL.
 GO:0045298; C:tubulin complex; IEA:Compara.
 GO:0005509; F:calcium ion binding; IEA:Compara.
 GO:0043066; P:negative regulation of apoptotic process; IDA:MGI.
 GO:2000384; P:negative regulation of ectoderm development; IMP:BHF-UCL.
 GO:0009615; P:response to virus; IEA:Compara.
 GO:0019827; P:stem cell maintenance; IMP:BHF-UCL. 

Interpro

 IPR011057; Mss4-like.
 IPR011323; Mss4/transl-control_tumor.
 IPR018103; Translation_control_tumour_CS.
 IPR018105; Translational_control_tumour_p. 

Pfam

 PF00838; TCTP 

SMART

  

PROSITE

 PS01002; TCTP_1
 PS01003; TCTP_2 

PRINTS

 PR01653; TCTPROTEIN.