UniProt Accession

 PTMS_HUMAN; P20962 

Genbank Protein ID

 M24398 

Genbank Nucleotide ID

 AAA61185.1 

Protein Name

 Parathymosin 

Protein Synonyms/Alias

  

Gene Name

 PTMS 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
4	****MSEKSVEAAAE	acetylation	[1]
4	****MSEKSVEAAAE	ubiquitination	[2]
15	AAAELSAKDLKEKKE	acetylation	[1]
15	AAAELSAKDLKEKKE	ubiquitination	[2, 3]
92	EEDEADPKRQKTENG	acetylation	[1]
92	EEDEADPKRQKTENG	ubiquitination	[3]

Reference

 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Parathymosin may mediate immune function by blocking the effect of prothymosin alpha which confers resistance to certain opportunistic infections. 

Sequence Annotation

 MOD_RES 2 2 N-acetylserine.
 MOD_RES 4 4 N6-acetyllysine.
 MOD_RES 5 5 Phosphoserine.
 MOD_RES 15 15 N6-acetyllysine.
 MOD_RES 92 92 N6-acetyllysine.  

Keyword

 Acetylation; Complete proteome; Direct protein sequencing; Immunity; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 102 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; TAS:ProtInc.
 GO:0006260; P:DNA replication; TAS:ProtInc. 

Interpro

 IPR004931; Pro/parathymosin. 

Pfam

 PF03247; Prothymosin 

SMART

  

PROSITE

  

PRINTS