| Tag | Content |
|---|
| CPLM ID | CPLM-024642 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | RNA-binding protein 5 |
Protein Synonyms/Alias | RNA-binding motif protein 5 |
Gene Name | Rbm5 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 542 | KTAQQIAKDMERWAK | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Component of the spliceosome A complex. Regulates alternative splicing of a number of mRNAs. May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron. May both positively and negatively regulate aopotosis by regulating the alternative splicing of several genes involved in this process, including FAS and CASP2/caspase-2. In the case of FAS, promotes production of a soluble form of FAS that inhibits apoptosis. In the case of CASP2/caspase-2, promotes production of a catalytically active form of CASP2/Caspase-2 that induces apoptosis (By similarity). |
Sequence Annotation | DOMAIN 98 178 RRM 1.
DOMAIN 231 315 RRM 2.
DOMAIN 743 789 G-patch.
ZN_FING 181 210 RanBP2-type.
ZN_FING 647 672 C2H2-type.
REGION 321 809 Required for interaction with U2AF2 (By
REGION 452 535 Sufficient for interaction with ACIN1,
MOD_RES 69 69 Phosphoserine (By similarity).
MOD_RES 78 78 Phosphoserine (By similarity).
MOD_RES 621 621 Phosphoserine (By similarity).
MOD_RES 624 624 Phosphoserine (By similarity). |
Keyword | Apoptosis; Complete proteome; Metal-binding; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Reference proteome; Repeat; RNA-binding; Spliceosome; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 815 AA |
Protein Sequence | MGSDKRVSRT ERSGRYGSII DRDDRDERES RSRRRDSDYK RSSDDRRGDR YDDYRDYDSP 60
ERERERRNSD RSEDGYHSDG DYGEHDYRHD ISDERESKTI MLRGLPITIT ESDIREMMES 120
FEGPQPADVR LMKRKTGVSR GFAFVEFYHL QDATSWMEAN QKKLVIQGKH IAMHYSNPRP 180
KFEDWLCNKC CLNNFRKRLK CFRCGADKFD SEQEVPPGTT ESVQSVDYYC DTIILRNIAP 240
HTVVDSIMTA LSPYASLAVN NIRLIKDKQT QQNRGFAFVQ LSSAMDASQL LQILQSLHPP 300
LKIDGKTIGV DFAKSARKDL VLPDGNRVSA FSVASTAIAA AQWSSTQSQS GEGGNVDYSY 360
MQPGQDGYTQ YTQYSQDYQQ FYQQQTGGLE SDASATSGTT VTTTSAAVVS QSPQLYNQTS 420
NPPGSPTEEA QPSTSTSTQA PAASPTGVVP GTKYAVPDTS TYQYDESSGY YYDPTTGLYY 480
DPNSQYYYNS LTQQYLYWDG EKETYVPAAE SSSNQQAGLP STKEGKEKKE KPKSKTAQQI 540
AKDMERWAKS LNKQKENFKN SFQPVNSLRE EERRESAAAD AGFALFEKKG ALAERQQLIP 600
ELVRNGDEEN PLKRGLVAAY SGDSDNEEEL VERLESEEEK LADWKKMACL LCRRQFPNRD 660
ALVRHQQLSD LHKQNMDIYR RSRLSEQELE ALELREREMK YRDRAAERRE KYGIPEPPEP 720
KRKKQFDAGT VNYEQPTKDG IDHSNIGNKM LQAMGWREGS GLGRKCQGIT APIEAQVRLK 780
GAGLGAKGSA YGLSGADSYK DAVRKAMFAR FTEME 815 |
Gene Ontology | GO:0005634; C:nucleus; ISS:UniProtKB. GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW. GO:0003729; F:mRNA binding; ISS:UniProtKB. GO:0000166; F:nucleotide binding; IEA:InterPro. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0006915; P:apoptotic process; IEA:UniProtKB-KW. GO:0043065; P:positive regulation of apoptotic process; ISS:UniProtKB. GO:0000381; P:regulation of alternative mRNA splicing, via spliceosome; ISS:UniProtKB. GO:0000245; P:spliceosomal complex assembly; ISS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |