UniProt Accession

 EAF6_YEAST; P47128; D6VWQ1 

Genbank Protein ID

 Z49581; L47993; AY557889; BK006943 

Genbank Nucleotide ID

 CAA89609.1; AAB39305.1; AAS56215.1; DAA08867.1 

Protein Name

 Chromatin modification-related protein EAF6 

Protein Synonyms/Alias

 ESA1-associated factor 6 

Gene Name

 EAF6 

Gene Synonyms/Alias

 YJR082C; J1854 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
78	KGFDTFSKSHHSHAD	acetylation	[1]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 

Functional Description

 Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Component of the NuA3 histone acetyltransferase complex, that acetylates Lys-14 of histone H3. Recruitment of NuA3 to nucleosomes requires methylated histone H3. In conjunction with the FACT complex, NuA3 may be involved in transcriptional regulation. 

Sequence Annotation

  

Keyword

 Chromatin regulator; Coiled coil; Complete proteome; DNA damage; DNA repair; Nucleus; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 113 AA 

Protein Sequence

Gene Ontology

 GO:0033100; C:NuA3 histone acetyltransferase complex; IDA:SGD.
 GO:0035267; C:NuA4 histone acetyltransferase complex; IPI:SGD.
 GO:0006281; P:DNA repair; IDA:SGD.
 GO:0016573; P:histone acetylation; IPI:SGD.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR015418; Hist_AcTrfase_NuA4_cplx. 

Pfam

 PF09340; NuA4 

SMART

  

PROSITE

  

PRINTS