CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006601
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Arrestin-related trafficking adapter 6 
Protein Synonyms/Alias
 Arrestin-like protein 1 
Gene Name
 ALY1 
Gene Synonyms/Alias
 ART6; YKR021W 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
379FHFAPLDKVTLHRIRubiquitination[1, 2]
414RRLEPTKKFLLAEHNubiquitination[2]
481HPDTNYDKIKAHHWIubiquitination[2]
627QLVANIYKPNQIPREubiquitination[2]
706YYDTSSSKIPELKLNubiquitination[2]
Reference
 [1] A perturbed ubiquitin landscape distinguishes between ubiquitin in trafficking and in proteolysis.
 Ziv I, Matiuhin Y, Kirkpatrick DS, Erpapazoglou Z, Leon S, Pantazopoulou M, Kim W, Gygi SP, Haguenauer-Tsapis R, Reis N, Glickman MH, Kleifeld O.
 Mol Cell Proteomics. 2011 May;10(5):M111.009753. [PMID: 21427232]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 
Functional Description
 May regulate endocytosis by recruiting RSP5 ubiquitin ligase activity to specific plasma membrane proteins in response to extracellular stimuli. 
Sequence Annotation
 MOD_RES 220 220 Phosphoserine.  
Keyword
 Complete proteome; Cytoplasm; Phosphoprotein; Reference proteome; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 915 AA 
Protein Sequence
MLQFNTENDT VAPVFPMEQD INAAPDAVPL VQTTTLQVFV KLAEPIVFLK GFETNGLSEI 60
APSILRGSLI VRVLKPNKLK SISITFKGIS RTEWPEGIPP KREEFSDVET VVNHTWPFYQ 120
ADDGMNSFTL EHHSSNNSSN RPSMSDEDYL LEKSGASVYI PPTAEPPKDN SNLSLDAYER 180
NSLSSDNLSN KPVSSDVSHD DSKLLAIQKT PLPSSSRRGS VPANFHGNSL SPHTFISDLF 240
TKTFSNSGAT PSPEQEDNYL TPSKDSKEVF IFRPGDYIYT FEQPISQSYP ESIKANFGSV 300
EYKLSIDIER FGAFKSTIHT QLPIKVVRLP SDGSVEETEA IAISKDWKDL LHYDVVIFSK 360
EIVLNAFLPI DFHFAPLDKV TLHRIRIYLT ESMEYTCNSN GNHEKARRLE PTKKFLLAEH 420
NGPKLPHIPA GSNPLKAKNR GNILLDEKSG DLVNKDFQFE VFVPSKFTNS IRLHPDTNYD 480
KIKAHHWIKI CLRLSKKYGD NRKHFEISID SPIHILNQLC SHANTLLPSY ESHFQYCDED 540
GNFAPAADQQ NYASHHDSNI FFPKEVLSSP VLSPNVQKMN IRIPSDLPVV RNRAESVKKS 600
KSDNTSKKND QSSNVFASKQ LVANIYKPNQ IPRELTSPQA LPLSPITSPI LNYQPLSNSP 660
PPDFDFDLAK RGAADSHAIP VDPPSYFDVL KADGIELPYY DTSSSKIPEL KLNKSRETLA 720
SIEEDSFNGW SQIDDLSDED DNDGDIASGF NFKLSTSAPS ENVNSHTPIL QSLNMSLDGR 780
KKNRASLHAT SVLPSTIRQN NQHFNDINQM LGSSDEDAFP KSQSLNFNKK LPILKINDNV 840
IQSNSNSNNR VDNPEDTVDS SVDITAFYDP RMSSDSKFDW EVSKNHVDPA AYSVNVASEN 900
RVLDDFKKAF REKRK 915 
Gene Ontology
 GO:0005769; C:early endosome; IDA:SGD.
 GO:0005770; C:late endosome; IDA:SGD.
 GO:2000397; P:positive regulation of ubiquitin-dependent endocytosis; IGI:SGD.
 GO:0032386; P:regulation of intracellular transport; IMP:SGD.
 GO:0070086; P:ubiquitin-dependent endocytosis; ISA:SGD. 
Interpro
 IPR011022; Arrestin_C-like. 
Pfam
 PF02752; Arrestin_C 
SMART
 SM01017; Arrestin_C 
PROSITE
  
PRINTS