| Tag | Content |
|---|
| CPLM ID | CPLM-000177 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Netrin receptor UNC5C |
Protein Synonyms/Alias | Protein unc-5 homolog 3; Protein unc-5 homolog C; Rostral cerebellar malformation protein |
Gene Name | Unc5c |
Gene Synonyms/Alias | Rcm; Unc5h3 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 448 | GFQPVNIKAARQDLL | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. Also involved in corticospinal tract axon guidances independently of DCC. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. |
Sequence Annotation | DOMAIN 62 159 Ig-like.
DOMAIN 161 256 Ig-like C2-type.
DOMAIN 260 314 TSP type-1 1.
DOMAIN 316 368 TSP type-1 2.
DOMAIN 528 634 ZU5.
DOMAIN 850 929 Death.
REGION 694 712 Interaction with DCC (By similarity).
MOD_RES 568 568 Phosphotyrosine.
CARBOHYD 236 236 N-linked (GlcNAc...) (Potential).
CARBOHYD 361 361 N-linked (GlcNAc...) (Potential).
DISULFID 83 142 By similarity.
DISULFID 188 239 By similarity.
DISULFID 272 309 By similarity.
DISULFID 276 313 By similarity.
DISULFID 287 299 By similarity. |
Keyword | Alternative splicing; Apoptosis; Complete proteome; Developmental protein; Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane; Phosphoprotein; Receptor; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 931 AA |
Protein Sequence | MRKGLRATAA RCGLGLGYLL QMLVLPALAL LSASGTGSAA QDDEFFHELP ETFPSDPPEP 60
LPHFLIEPEE AYIVKNKPVN LYCKASPATQ IYFKCNSEWV HQKDHVVDER VDETSGLIVR 120
EVSIEISRQQ VEELFGPEDY WCQCVAWSSA GTTKSRKAYV RIAYLRKTFE QEPLGKEVSL 180
EQEVLLQCRP PEGIPVAEVE WLKNEDIIDP AEDRNFYITI DHNLIIKQAR LSDTANYTCV 240
AKNIVAKRKS TTATVIVYVN GGWSTWTEWS VCNSRCGRGY QKRTRTCTNP APLNGGAFCE 300
GQSVQKIACT TLCPVDGRWT SWSKWSTCGT ECTHWRRREC TAPAPKNGGK DCDGLVLQSK 360
NCTDGLCMQG FIYPISTEHR PQNEYGFSSA PDSDDVALYV GIVIAVTVCL AITVVVALFV 420
YRKNHRDFES DIIDSSALNG GFQPVNIKAA RQDLLAVPPD LTSAAAMYRG PVYALHDVSD 480
KIPMTNSPIL DPLPNLKIKV YNSSGAVTPQ DDLAEFSSKL SPQMTQSLLE NEALNLKNQS 540
LARQTDPSCT AFGTFNSLGG HLIIPNSGVS LLIPAGAIPQ GRVYEMYVTV HRKENMRPPM 600
EDSQTLLTPV VSCGPPGALL TRPVILTLHH CADPSTEDWK IQLKNQAVQG QWEDVVVVGE 660
ENFTTPCYIQ LDAEACHILT ENLSTYALVG QSTTKAAAKR LKLAIFGPLC CSSLEYSIRV 720
YCLDDTQDAL KEVLQLERQM GGQLLEEPKA LHFKGSIHNL RLSIHDIAHS LWKSKLLAKY 780
QEIPFYHIWS GSQRNLHCTF TLERLSLNTV ELVCKLCVRQ VEGEGQIFQL NCTVSEEPTG 840
IDLPLLDPAS TITTVTGPSA FSIPLPIRQK LCSSLDAPQT RGHDWRMLAH KLNLDRYLNY 900
FATKSSPTGV ILDLWEAQNF PDGNLSMLAA VLEEMGRHET VVSLAAEGQY 950 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005886; C:plasma membrane; IDA:MGI. GO:0005042; F:netrin receptor activity; IDA:MGI. GO:0033564; P:anterior/posterior axon guidance; IMP:MGI. GO:0006915; P:apoptotic process; IEA:UniProtKB-KW. GO:0007420; P:brain development; IMP:MGI. GO:0043065; P:positive regulation of apoptotic process; IMP:MGI. GO:0030334; P:regulation of cell migration; IMP:MGI. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |