UniProt Accession

 ADRO_HUMAN; P22570; B4DDI7; B4DHX5; B4DQQ4; B4DX24; B7Z7G2; E7EQC1; Q13716; Q4PJI0; Q9BU12 

Genbank Protein ID

 J03826; J03826; M58509; M58508; M58509; M58508; DQ085780; AK293208; AK295307; AK298908; AK301779; AK301977; AC068874; BC002960 

Genbank Nucleotide ID

 AAB59498.1; AAB59497.1; AAA51668.1; AAA51668.1; AAA51669.1; AAA51669.1; AAY68215.1; BAG56748.1; BAG58287.1; BAG61016.1; BAG63236.1; BAH13598.1; AAH02960.1 

Protein Name

 NADPH:adrenodoxin oxidoreductase, mitochondrial 

Protein Synonyms/Alias

 AR; Adrenodoxin reductase; Ferredoxin--NADP(+) reductase; Ferredoxin reductase 

Gene Name

 FDXR 

Gene Synonyms/Alias

 ADXR 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
215	CQRTDITKAALGVLR	ubiquitination	[1]
271	DFLGLQDKIKEVPRP	ubiquitination	[1]
382	PSVPFDSKLGVIPNV	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Serves as the first electron transfer protein in all the mitochondrial P450 systems. Including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver. 

Sequence Annotation

 NP_BIND 184 187 NADP (By similarity).
 NP_BIND 228 229 NADP (By similarity).
 NP_BIND 405 407 FAD (By similarity).
 BINDING 49 49 FAD; via amide nitrogen (By similarity).
 BINDING 69 69 FAD (By similarity).
 BINDING 77 77 FAD; via amide nitrogen (By similarity).
 BINDING 113 113 FAD; via amide nitrogen and carbonyl
 BINDING 240 240 NADP (By similarity).
 BINDING 398 398 FAD; via amide nitrogen (By similarity).
 BINDING 405 405 NADP; via amide nitrogen (By similarity).  

Keyword

 Alternative splicing; Cholesterol metabolism; Complete proteome; Electron transport; FAD; Flavoprotein; Lipid metabolism; Mitochondrion; NADP; Oxidoreductase; Polymorphism; Reference proteome; Steroid metabolism; Sterol metabolism; Transit peptide; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 491 AA 

Protein Sequence

Gene Ontology

 GO:0005743; C:mitochondrial inner membrane; IEA:Compara.
 GO:0005759; C:mitochondrial matrix; TAS:Reactome.
 GO:0004324; F:ferredoxin-NADP+ reductase activity; TAS:ProtInc.
 GO:0070402; F:NADPH binding; IEA:Compara.
 GO:0015039; F:NADPH-adrenodoxin reductase activity; IEA:Compara.
 GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-UniPathway.
 GO:0022900; P:electron transport chain; IEA:UniProtKB-KW.
 GO:0006091; P:generation of precursor metabolites and energy; TAS:ProtInc.
 GO:0070995; P:NADPH oxidation; IEA:Compara.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome.
 GO:0006694; P:steroid biosynthetic process; TAS:ProtInc. 

Interpro

 IPR021163; Adrenodoxin_Rdtase.
 IPR016040; NAD(P)-bd_dom. 

Pfam

  

SMART

  

PROSITE

  

PRINTS