| Tag | Content |
|---|
| CPLM ID | CPLM-023325 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Dual specificity tyrosine-phosphorylation-regulated kinase 2 |
Protein Synonyms/Alias | Protein smell impaired at 35A; dDyrk2 |
Gene Name | smi35A |
Gene Synonyms/Alias | Dyrk2; CG4551 |
Created Date | July 27, 2013 |
Organism | Drosophila melanogaster (Fruit fly) |
NCBI Taxa ID | 7227 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 588 | IKLSASDKYNSMQKV | acetylation | [1] |
|
Reference | [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation. Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C. Sci Signal. 2011 Jul 26;4(183):ra48. [ PMID: 21791702] |
Functional Description | In vitro; can phosphorylate exogenous substrates on Ser and Thr residues. May have a physiological role in development being involved in cellular growth and differentiation. |
Sequence Annotation | DOMAIN 198 494 Protein kinase.
NP_BIND 204 212 ATP (By similarity).
ACT_SITE 324 324 Proton acceptor (By similarity).
BINDING 227 227 ATP (By similarity).
MOD_RES 25 25 Phosphoserine.
MOD_RES 356 356 Phosphotyrosine; by autocatalysis.
MOD_RES 358 358 Phosphotyrosine; by autocatalysis. |
Keyword | ATP-binding; Complete proteome; Cytoplasm; Kinase; Magnesium; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase; Tyrosine-protein kinase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 722 AA |
Protein Sequence | MLDRCEMPIQ LDNEKLRRDV RLSGSRLDLP QLCNGSRRLD GHNNHVAANE NTVTTTSLNG 60
NGNGNGNSNS NNNNNIGSPV SSSTTNSSNG GNERGSSTKS NSSSGSGSSG NSASSTGSGE 120
LKCNTPMTPS ELVKKFRNYL TDLEFEELKV YKEVWYFGQH ASKNYNKPAP TANTTNLGYD 180
DDNGNYKIIE HDHIAFRYEI LEVIGKGSFG QVIRALDHKT NTHVAIKIIR NKKRFLNQAV 240
VELNILDELR EKDADGSHNV IHMLDYTYFR KHLCITFELM SLNLYELIKK NNYNGFSMSL 300
IRRFCNSIVK CLRLLYKENI IHCDLKPENI LLKQRGSSSI KVIDFGSSCY VDRKIYTYIQ 360
SRFYRSPEVI LGLQYGTAID MWSLGCILAE LYTGFPLFPG ENEVEQLACI MEVLGLPPKV 420
LISVARRRRL FFDSRDAPRC ITNTKGRKRS PGSKSLAHIL HCQDRYFIDF LQRCLEWDPA 480
ERMTPDEAAH HEFLQPSASS RHRSCRMSSS SSSSGLNSVS QKSSCYSFSE ISPGTNGPVV 540
ASITSTTAVH NAAIATTTKS RQQPPSQSHG HAQSNGHLPD IKLSASDKYN SMQKVAVRSK 600
ITSSVSDLES VQQYSLHRIY GGVGSGSTHH VSSAATRKHL PGTGSGIVGA MSSKYGSSTL 660
AHNHHNVTHH NASTATIATT THHHHHHGGQ QQQQSSSGAS TMAMSHSQST GDVSDRAIFG 720
RA 722 |
Gene Ontology | GO:0005829; C:cytosol; IDA:UniProtKB. GO:0005524; F:ATP binding; IDA:UniProtKB. GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB. GO:0004712; F:protein serine/threonine/tyrosine kinase activity; IEA:EC. GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW. GO:0042048; P:olfactory behavior; IMP:FlyBase. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |