UniProt Accession

 MFF_HUMAN; Q9GZY8; Q567U1; Q658R6; Q9BVZ1; Q9H690; Q9NRG8 

Genbank Protein ID

 AK026137; AF246239; AF226049; AF258660; AC097662; BC000797; BC093024; AL833032 

Genbank Nucleotide ID

 BAB15373.1; AAG44486.1; AAF86949.1; AAG44658.1; AAY24252.1; AAH00797.1; AAH93024.1; CAH56328.1 

Protein Name

 Mitochondrial fission factor 

Protein Synonyms/Alias

  

Gene Name

 MFF 

Gene Synonyms/Alias

 C2orf33; AD030; AD033; GL004 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
28	MRVPEKLKVAPPNAD	ubiquitination	[1]
88	PFKPLALKTPPRVLT	ubiquitination	[1]
251	SLRRQIIKLNRRLQL	ubiquitination	[1]
264	QLLEEENKERAKREM	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Plays a role in mitochondrial and peroxisomal fission. 

Sequence Annotation

 MOD_RES 115 115 Phosphothreonine.
 MOD_RES 155 155 Phosphoserine.
 MOD_RES 157 157 Phosphoserine.
 MOD_RES 172 172 Phosphoserine (By similarity).
 MOD_RES 200 200 Phosphothreonine.
 MOD_RES 202 202 Phosphoserine.
 MOD_RES 229 229 Phosphoserine.
 MOD_RES 233 233 Phosphoserine.  

Keyword

 Alternative splicing; Coiled coil; Complete proteome; Membrane; Mitochondrion; Mitochondrion outer membrane; Phosphoprotein; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 342 AA 

Protein Sequence

Gene Ontology

 GO:0032592; C:integral to mitochondrial membrane; IDA:UniProtKB.
 GO:0005741; C:mitochondrial outer membrane; IDA:UniProtKB.
 GO:0005777; C:peroxisome; IDA:UniProtKB.
 GO:0043653; P:mitochondrial fragmentation involved in apoptotic process; IMP:UniProtKB.
 GO:0070584; P:mitochondrion morphogenesis; IMP:MGI.
 GO:0016559; P:peroxisome fission; IMP:UniProtKB.
 GO:0090200; P:positive regulation of release of cytochrome c from mitochondria; IMP:UniProtKB.
 GO:0051260; P:protein homooligomerization; IDA:UniProtKB.
 GO:0006626; P:protein targeting to mitochondrion; IMP:UniProtKB.
 GO:1900063; P:regulation of peroxisome organization; IMP:UniProtKB.
 GO:0001836; P:release of cytochrome c from mitochondria; IMP:UniProtKB. 

Interpro

 IPR008518; FATE/Miff/Tango-11. 

Pfam

 PF05644; Miff 

SMART

  

PROSITE

  

PRINTS