| Tag | Content |
|---|
| CPLM ID | CPLM-021258 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | GDNF-inducible zinc finger protein 1 |
Protein Synonyms/Alias | Zinc finger and BTB domain-containing protein 23; Zinc finger protein 336 |
Gene Name | GZF1 |
Gene Synonyms/Alias | ZBTB23; ZNF336 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 117 | LEVAEKLKCLDLSET | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Transcriptional repressor. Binds the GZF1 responsive element (GRE) (consensus: 5'-TGCGCN[TG][CA]TATA-3'). May be regulating VSX2/HOX10 expression. |
Sequence Annotation | DOMAIN 31 103 BTB.
ZN_FING 317 340 C2H2-type 1.
ZN_FING 348 371 C2H2-type 2.
ZN_FING 377 400 C2H2-type 3.
ZN_FING 407 429 C2H2-type 4.
ZN_FING 435 457 C2H2-type 5.
ZN_FING 463 485 C2H2-type 6.
ZN_FING 491 513 C2H2-type 7.
ZN_FING 519 541 C2H2-type 8.
ZN_FING 547 569 C2H2-type 9.
ZN_FING 575 597 C2H2-type 10. |
Keyword | Complete proteome; DNA-binding; Metal-binding; Nucleus; Polymorphism; Reference proteome; Repeat; Repressor; Transcription; Transcription regulation; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 711 AA |
Protein Sequence | MESGAVLLES KSSPFNLLHE MHELRLLGHL CDVTVSVEYQ GVRKDFMAHK AVLAATSKFF 60
KEVFLNEKSV DGTRTNVYLN EVQVADFASF LEFVYTAKVQ VEEDRVQRML EVAEKLKCLD 120
LSETCFQLKK QMLESVLLEL QNFSESQEVE VSSGSQVSAA PAPRASVATD GPHPSGLTDS 180
LDYPGERASN GMSSDLPPKK SKDKLDKKKE VVKPPYPKIR RASGRLAGRK VFVEIPKKKY 240
TRRLREQQKT AEGDVGDYRC PQDQSPDRVG TEMEQVSKNE GCQAGAELEE LSKKAGPEEE 300
EEEEEEDEEG EKKKSNFKCS ICEKAFLYEK SFLKHSKHRH GVATEVVYRC DTCGQTFANR 360
CNLKSHQRHV HSSERHFPCE LCGKKFKRKK DVKRHVLQVH EGGGERHRCG QCGKGLSSKT 420
ALRLHERTHT GDRPYGCTEC GARFSQPSAL KTHMRIHTGE KPFVCDECGA RFTQNHMLIY 480
HKRCHTGERP FMCETCGKSF ASKEYLKHHN RIHTGSKPFK CEVCFRTFAQ RNSLYQHIKV 540
HTGERPYCCD QCGKQFTQLN ALQRHRRIHT GERPFMCNAC GRTFTDKSTL RRHTSIHDKN 600
TPWKSFLVIV DGSPKNDDGH KTEQPDEEYV SSKLSDKLLS FAENGHFHNL AAVQDTVPTM 660
QENSSADTAC KADDSVVSQD TLLATTISEL SELTPQTDSM PTQLHSLSNM E 711 |
Gene Ontology | GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell. GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell. GO:0043565; F:sequence-specific DNA binding; IDA:UniProtKB. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0001658; P:branching involved in ureteric bud morphogenesis; IEA:Compara. GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Compara. GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:UniProtKB. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |