CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039665
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Mediator of RNA polymerase II transcription subunit 24 
Protein Synonyms/Alias
  
Gene Name
 MED24 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
736VLTDIFAKVLEKGWVubiquitination[1, 2]
740IFAKVLEKGWVDSRSubiquitination[1, 2, 3]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1008 AA 
Protein Sequence
MKVVNLKQAI LQAWKERWSD YQWAINMKKF FPKGATWDIL NLADALLEQA MIGPSPNPLI 60
LSYLKYAISS QMVSYSSVLT AISKFDDFSR DLCVQALLDI MDMFCDRLSC HGKAEECIGL 120
CRALLSALHW LLRCTAASAE RLREGLEAGT PAAGEKQLAM CLQRLEKTLS STKNRALLHI 180
AKLEEASLHT SQGLGQGGTR ANQPTASWTA IEHSLLKLGE ILANLSNPQL RSQAEQCGTL 240
IRSIPTMLSV HAEQMHKTGF PTVHAVILLE GTMNLTGETQ SLVEQLTMVK RMQHIPTPLF 300
VLEIWKACFV GLIESPEGTE ELKWTAFTFL KIPQVLVKLK KYSHGDKDFT EDVNCAFEFL 360
LKLTPLLDKA DQRCNCDCTN FLLQECGKQG LLSEASVNNL MAKRKADREH APQQKSGENA 420
NIQPNIQLIL RAEPTVTNIL KTMDADHSKS PEGLLGVLGH MLSGKSLDLL LAAAAATGKL 480
KSFARKFINL NEFTTYGSEE STKPASVRAL LFDISFLMLC HVAQTYGSEV ILSESRTGAE 540
VPFFETWMQT CMPEEGKILN PDHPCFRPDS TKVESLVALL NNSSEMKLVQ MKWHEACLSI 600
SAAILEILNA WENGVLAFES IQKITDNIKG KVCSLAVCAV AWLVAHVRML GLDEREKSLQ 660
MIRQLAGPLF SENTLQFYNE RVVIMNSILE RMCADVLQQT ATQIKFPSTG VDTMPYWNLL 720
PPKRPIKEVL TDIFAKVLEK GWVDSRSIHI FDTLLHMGGV YWFCNNLIKE LLKETRKEHT 780
LRAVELLYSI FCLDMQQVTL VLLGHILPGL LTDSSKWHSL MDPPGTALAK LAVWCALSSY 840
SSHKGQASTR QKKRHREDIE DYISLFPLDD VQPSKLMRLL SSNEDDANIL SSPTDRSMSS 900
SLSASQLHTV NMRDPLNRVL ANLFLLISSI LGSRTAGPHT QFVQWFMEEC VDCLEQGGRG 960
SVLQFMPFTT VSELVKVSAM SSPKVVLAIT DLSLPLGRQV AAKAIAAL 1008 
Gene Ontology
  
Interpro
 IPR021429; Mediator_Med24_N. 
Pfam
 PF11277; Med24_N 
SMART
  
PROSITE
  
PRINTS