CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-045133
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 2',3'-cyclic-nucleotide 3'-phosphodiesterase 
Protein Synonyms/Alias
  
Gene Name
 CNP 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
138QLSADDLKKLKPGLEacetylation[1]
138QLSADDLKKLKPGLEubiquitination[2, 3]
139LSADDLKKLKPGLEKubiquitination[4, 5]
Reference
 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 165 AA 
Protein Sequence
MDEDTVATLL ECKTLFILRG LPGSGKSTLA RVIVDKYRDG TKMVSADAYK ITPGARGAFS 60
EEYKRLDEDL AAYCRRRDIR ILVLDDTNHE RERLEQLFEM ADQYQYQVVL VEPKTAWRLD 120
CAQLKEKNQW QLSADDLKKL KPGLEKDFLP LYFGWFLTKK SSETL 165 
Gene Ontology
 GO:0016020; C:membrane; IEA:InterPro.
 GO:0004113; F:2',3'-cyclic-nucleotide 3'-phosphodiesterase activity; IEA:InterPro.
 GO:0009214; P:cyclic nucleotide catabolic process; IEA:InterPro. 
Interpro
 IPR008431; CNPase.
 IPR027417; P-loop_NTPase. 
Pfam
  
SMART
  
PROSITE
  
PRINTS