UniProt Accession

 HA1B_MOUSE; P01901 

Genbank Protein ID

 J00400; U47328; V00746; V00747 

Genbank Nucleotide ID

 AAA39648.1; AAB17606.1; CAA24119.2; CAA24119.2 

Protein Name

 H-2 class I histocompatibility antigen, K-B alpha chain 

Protein Synonyms/Alias

 H-2K(B) 

Gene Name

 H2-K1 

Gene Synonyms/Alias

 H2-K 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
194	EWLRRYLKNGNATLL	ubiquitination	[1]
338	RRRNTGGKGGDYALA	ubiquitination	[1]
359	DLSLPDCKVMVHDPH	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Involved in the presentation of foreign antigens to the immune system. 

Sequence Annotation

 DOMAIN 206 294 Ig-like C1-type.
 REGION 22 111 Alpha-1.
 REGION 112 203 Alpha-2.
 REGION 204 295 Alpha-3.
 REGION 296 305 Connecting peptide.
 MOD_RES 354 354 Phosphoserine (By similarity).
 CARBOHYD 107 107 N-linked (GlcNAc...).
 CARBOHYD 197 197 N-linked (GlcNAc...).
 DISULFID 122 185
 DISULFID 224 280  

Keyword

 3D-structure; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Immunity; Membrane; MHC I; Phosphoprotein; Reference proteome; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 369 AA 

Protein Sequence

Gene Ontology

 GO:0009897; C:external side of plasma membrane; IDA:MGI.
 GO:0071556; C:integral to lumenal side of endoplasmic reticulum membrane; TAS:Reactome.
 GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW.
 GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome.
 GO:0042605; F:peptide antigen binding; IDA:MGI.
 GO:0002485; P:antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent; IDA:MGI.
 GO:0042590; P:antigen processing and presentation of exogenous peptide antigen via MHC class I; IDA:MGI.
 GO:0042742; P:defense response to bacterium; IDA:MGI.
 GO:0006955; P:immune response; IEA:InterPro.
 GO:0048839; P:inner ear development; IDA:MGI.
 GO:0001916; P:positive regulation of T cell mediated cytotoxicity; IDA:MGI. 

Interpro

 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR003006; Ig/MHC_CS.
 IPR003597; Ig_C1-set.
 IPR011161; MHC_I-like_Ag-recog.
 IPR011162; MHC_I/II-like_Ag-recog.
 IPR001039; MHC_I_a_a1/a2.
 IPR010579; MHC_I_a_C. 

Pfam

 PF07654; C1-set
 PF00129; MHC_I
 PF06623; MHC_I_C 

SMART

 SM00407; IGc1 

PROSITE

 PS50835; IG_LIKE
 PS00290; IG_MHC 

PRINTS

 PR01638; MHCCLASSI.