UniProt Accession

 DEOD_ECOLI; P0ABP8; P09743; Q2M5T3 

Genbank Protein ID

 M60917; U14003; U00096; AP009048; X05629 

Genbank Nucleotide ID

 AAA24401.1; AAA97280.1; AAC77337.1; BAE78373.1; CAA29114.1 

Protein Name

 Purine nucleoside phosphorylase DeoD-type 

Protein Synonyms/Alias

 PNP; Inosine phosphorylase 

Gene Name

 deoD 

Gene Synonyms/Alias

 pup; b4384; JW4347 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
27	PGDPLRAKYIAETFL	acetylation	[1, 2]
54	LGFTGTYKGRKISVM	acetylation	[2, 3]
84	LITDFGVKKIIRVGS	acetylation	[2, 3]
100	GAVLPHVKLRDVVIG	acetylation	[2]
122	KVNRIRFKDHDFAAI	acetylation	[2]
143	RNAVDAAKALGIDAR	acetylation	[2]
227	TTFNDMIKIALESVL	acetylation	[3]
238	ESVLLGDKE******	acetylation	[2]

Reference

 [1] Lysine acetylation is a highly abundant and evolutionarily conserved modification in Escherichia coli.
 Zhang J, Sprung R, Pei J, Tan X, Kim S, Zhu H, Liu CF, Grishin NV, Zhao Y.
 Mol Cell Proteomics. 2009 Feb;8(2):215-25. [PMID: 18723842]
 [2] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618]
 [3] Comprehensive profiling of protein lysine acetylation in Escherichia coli.
 Zhang K, Zheng S, Yang JS, Chen Y, Cheng Z.
 J Proteome Res. 2013 Feb 1;12(2):844-51. [PMID: 23294111] 

Functional Description

 Cleavage of guanosine or inosine to respective bases and sugar-1-phosphate molecules. 

Sequence Annotation

 MOD_RES 27 27 N6-acetyllysine.  

Keyword

 3D-structure; Acetylation; Complete proteome; Direct protein sequencing; Glycosyltransferase; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 239 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:UniProtKB.
 GO:0016020; C:membrane; IDA:UniProtKB.
 GO:0004731; F:purine-nucleoside phosphorylase activity; IDA:EcoCyc.
 GO:0006152; P:purine nucleoside catabolic process; IMP:EcoCyc.
 GO:0019686; P:purine nucleoside interconversion; IDA:EcoCyc.
 GO:0006974; P:response to DNA damage stimulus; IEP:EcoliWiki. 

Interpro

 IPR004402; DeoD-type.
 IPR018017; Nucleoside_phosphorylase.
 IPR018016; Nucleoside_phosphorylase_CS.
 IPR000845; Nucleoside_phosphorylase_d. 

Pfam

 PF01048; PNP_UDP_1 

SMART

  

PROSITE

 PS01232; PNP_UDP_1 

PRINTS