UniProt Accession

 K7EIF9_HUMAN; K7EIF9 

Genbank Protein ID

 AC087691; AC099811 

Genbank Nucleotide ID

  

Protein Name

 Signal transducer and activator of transcription 5A 

Protein Synonyms/Alias

  

Gene Name

 STAT5A 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
27	QDTENELKKLQQTQE	ubiquitination	[1]
28	DTENELKKLQQTQEY	ubiquitination	[2]
71	RETALQQKQVSLEAW	ubiquitination	[1, 2, 3]
99	ELAEKHQKTLQLLRK	ubiquitination	[2]
106	KTLQLLRKQQTIILD	ubiquitination	[2]

Reference

 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 142 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0005634; C:nucleus; IEA:InterPro.
 GO:0000979; F:RNA polymerase II core promoter sequence-specific DNA binding; IEA:Compara.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
 GO:0004871; F:signal transducer activity; IEA:Compara.
 GO:0019221; P:cytokine-mediated signaling pathway; IEA:Compara.
 GO:0046543; P:development of secondary female sexual characteristics; IEA:Compara.
 GO:0046544; P:development of secondary male sexual characteristics; IEA:Compara.
 GO:0060742; P:epithelial cell differentiation involved in prostate gland development; IEA:Compara.
 GO:0007565; P:female pregnancy; IEA:Compara.
 GO:0007259; P:JAK-STAT cascade; IEA:Compara.
 GO:0007595; P:lactation; IEA:Compara.
 GO:0019915; P:lipid storage; IEA:Compara.
 GO:0001553; P:luteinization; IEA:Compara.
 GO:0061180; P:mammary gland epithelium development; IEA:Compara.
 GO:0001779; P:natural killer cell differentiation; IEA:Compara.
 GO:0045647; P:negative regulation of erythrocyte differentiation; IEA:Compara.
 GO:0033026; P:negative regulation of mast cell apoptotic process; IEA:Compara.
 GO:0018108; P:peptidyl-tyrosine phosphorylation; IEA:Compara.
 GO:0048541; P:Peyer's patch development; IEA:Compara.
 GO:0042104; P:positive regulation of activated T cell proliferation; IEA:Compara.
 GO:0045579; P:positive regulation of B cell differentiation; IEA:Compara.
 GO:0045588; P:positive regulation of gamma-delta T cell differentiation; IEA:Compara.
 GO:0050729; P:positive regulation of inflammatory response; IEA:Compara.
 GO:0045086; P:positive regulation of interleukin-2 biosynthetic process; IEA:Compara.
 GO:0060376; P:positive regulation of mast cell differentiation; IEA:Compara.
 GO:0070668; P:positive regulation of mast cell proliferation; IEA:Compara.
 GO:0045931; P:positive regulation of mitotic cell cycle; IEA:Compara.
 GO:0040018; P:positive regulation of multicellular organism growth; IEA:Compara.
 GO:0032825; P:positive regulation of natural killer cell differentiation; IEA:Compara.
 GO:0045954; P:positive regulation of natural killer cell mediated cytotoxicity; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0060740; P:prostate gland epithelium morphogenesis; IEA:Compara.
 GO:0030155; P:regulation of cell adhesion; IEA:Compara.
 GO:0030856; P:regulation of epithelial cell differentiation; IEA:Compara.
 GO:0019218; P:regulation of steroid metabolic process; IEA:Compara.
 GO:0043434; P:response to peptide hormone stimulus; IEA:Compara.
 GO:0033077; P:T cell differentiation in thymus; IEA:Compara.
 GO:0043029; P:T cell homeostasis; IEA:Compara. 

Interpro

 IPR013800; STAT_TF_alpha.
 IPR015988; STAT_TF_coiled-coil.
 IPR001217; STAT_TF_core. 

Pfam

 PF01017; STAT_alpha 

SMART

  

PROSITE

  

PRINTS