CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016601
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Mucin-20 
Protein Synonyms/Alias
 MUC-20 
Gene Name
 Muc20 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
630TEHNAREKLMNQLRRacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 May regulate MET signaling cascade. Seems to decrease hepatocyte growth factor (HGF)-induced transient MAPK activation. Blocks GRB2 recruitment to MET thus suppressing the GRB2-RAS pathway. Inhibits HGF-induced proliferation of MMP1 and MMP9 expression (By similarity). 
Sequence Annotation
 REPEAT 180 188 1.
 REPEAT 189 197 2.
 REPEAT 198 206 3.
 REPEAT 210 218 4.
 REPEAT 219 227 5.
 REGION 180 227 Approximate repeats.
 REGION 399 603 Involved in oligomerization (By
 REGION 604 656 Interaction with MET (By similarity).
 CARBOHYD 366 366 N-linked (GlcNAc...) (Potential).
 CARBOHYD 570 570 N-linked (GlcNAc...) (Potential).  
Keyword
 Cell membrane; Cell projection; Complete proteome; Glycoprotein; Membrane; Reference proteome; Repeat; Secreted; Signal. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 656 AA 
Protein Sequence
MGSVWGLAVP LLVFCWKVGV SVSSPGLDIS RSVPLVTTNN MEVSTFTQRD RPSSERAFQT 60
TNLIQYVPLD TQTLSTESAS NALSATSISS EVNSRDTQTT SFVTKTRKTH TTTPAASSLE 120
AQTTSPNLST LNIQITSPIA SSLDAQTIFP VSLSLSTQTT SPAPSFLDTQ TTSPEPSSLT 180
TSPAPSSLIT SPTPSSLTTS PAPSFLDTQT TSPAPSSLTT SPAPSSLDTQ TISPIELTLK 240
TQTISTVTET RTVSIRIPSD LTVMHTIPTE TLAPSNSPRT GMSTVQTGTV WDSIEAVFDT 300
LCTDDSSEEA RKITVDLLTL AHTSTEVEYL SSESSSSSDS SAGVLSSSRV LGPDSATPAK 360
GLVAFNITHI KLSNCITEIE TTITISGAPG ASLSPTEATA ALFTSEILTL PPPTEAKPIF 420
PETTSLSGIL STAGTPALAT TLEGTVSTSA ITESETAVAQ TLTSVGTSVT VRRNPLENTS 480
TLSIETQSHT EVLGTITVPM VAGSTMGEAA SFVSFTALDS SSLSVVVTTE SSATSETLTT 540
GNTTNSSFLT ESHPPFSIYS TTASTSKNPN ITLTKTTASP KPPTHPTTSA STAWIRKTTK 600
HDPGEDGGFL LVRLTVASPK DLTEHNAREK LMNQLRRELH ARMPLVHMSF LSIRRG 656 
Gene Ontology
 GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.
 GO:0009925; C:basal plasma membrane; ISA:MGI.
 GO:0005829; C:cytosol; ISS:UniProtKB.
 GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
 GO:0031528; C:microvillus membrane; IEA:UniProtKB-SubCell.
 GO:0005741; C:mitochondrial outer membrane; ISS:UniProtKB.
 GO:0000187; P:activation of MAPK activity; IPI:MGI.
 GO:0030261; P:chromosome condensation; ISS:UniProtKB.
 GO:0048012; P:hepatocyte growth factor receptor signaling pathway; IDA:MGI.
 GO:0006917; P:induction of apoptosis; ISS:UniProtKB.
 GO:0051260; P:protein homooligomerization; ISA:MGI. 
Interpro
  
Pfam
  
SMART
  
PROSITE
  
PRINTS