CPLM-011678

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-011678

UniProt Accession

APRV1_MOUSE; Q09PK2; Q0VEV3; Q32P05; Q6PEP7; Q9D135

Genbank Protein ID

DQ841260; BC057938; BC108357; BC119099; BC119101; AK004007

Genbank Nucleotide ID

ABI23689.1; AAH57938.1; AAI08358.1; AAI19100.1; AAI19102.1; BAB23121.2

Protein Name

Retroviral-like aspartic protease 1

Protein Synonyms/Alias

Skin-specific retroviral-like aspartic protease; SASPase; Skin aspartic protease; TPA-inducible aspartic proteinase-like protein

Gene Name

Asprv1

Gene Synonyms/Alias

Sasp; Taps

Created Date

July 27, 2013

Organism

Mus musculus (Mouse)

NCBI Taxa ID

10090

Lysine Modification

Position	Peptide	Type	References
133	NHWDHATKLRFLKES	acetylation	[1]

Reference

[1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]

Functional Description

Sequence Annotation

DOMAIN 205 286 Peptidase A2.
ACT_SITE 210 210 By similarity.
CARBOHYD 39 39 N-linked (GlcNAc...) (Potential).
CARBOHYD 274 274 N-linked (GlcNAc...) (Potential).

Keyword

Aspartyl protease; Autocatalytic cleavage; Complete proteome; Direct protein sequencing; Glycoprotein; Hydrolase; Membrane; Protease; Reference proteome; Transmembrane; Transmembrane helix.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

339 AA

Protein Sequence

MRNPGGPGWA SKRPLQKKQN TACLCAQQPA RHFVPAPFNS SRQGKNTAQP TEPSLSSVIA 60
PTLFCAFLYL ACVTAELPEV SRRMATSGVR SKEGRREHAF VPEPFTGTNL APSLWLHRFE 120
VIDDLNHWDH ATKLRFLKES LKGDALDVYN GLSSQAQGDF SFVKQALLRA FGAPGEAFSE 180
PEEILFANSM GKGYYLKGKV GHVPVRFLVD SGAQVSVVHP ALWEEVTDGD LDTLRPFNNV 240
VKVANGAEMK ILGVWDTEIS LGKTKLKAEF LVANASAEEA IIGTDVLQDH NAVLDFEHRT 300
CTLKGKKFRL LPVGSSLEDE FDLELIEEEE GSSAPEGSH 339

Gene Ontology

GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0004190; F:aspartic-type endopeptidase activity; IDA:UniProtKB.
GO:0016485; P:protein processing; IDA:UniProtKB.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
GO:0043588; P:skin development; IMP:UniProtKB.

Interpro

IPR001995; Peptidase_A2_cat.
IPR021109; Peptidase_aspartic.
IPR001969; Peptidase_aspartic_AS.

Pfam

SMART

PROSITE

PS50175; ASP_PROT_RETROV
PS00141; ASP_PROTEASE

PRINTS