CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000630
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Branched-chain-amino-acid aminotransferase, mitochondrial 
Protein Synonyms/Alias
 BCAT(m) 
Gene Name
 Bcat2 
Gene Synonyms/Alias
 Bcatm; Eca40 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
142LCLPDFDKQELLECIacetylation[1]
Reference
 [1] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758] 
Functional Description
 Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. May also function as a transporter of branched chain alpha-keto acids. 
Sequence Annotation
 MOD_RES 230 230 N6-(pyridoxal phosphate)lysine (By
 MOD_RES 322 322 N6-acetyllysine (By similarity).  
Keyword
 Acetylation; Amino-acid biosynthesis; Aminotransferase; Branched-chain amino acid biosynthesis; Complete proteome; Mitochondrion; Pyridoxal phosphate; Reference proteome; Transferase; Transit peptide. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 393 AA 
Protein Sequence
MAAATLGQVW ARKLLPVPWL LCGSKRCVSS IFKAADLQIQ MTKEPQKKPA PSQALLFGKT 60
FTDHMLMVEW NNKAGWGPPR IQPFQNLTLH PACSGLHYSL QLFEGLKAYK GGDQQVRLFR 120
PWLNMDRMLR SARRLCLPDF DKQELLECIR QLIEVDKDWV PDGNGTSLYV RPVLIGNEPS 180
LGVGMVTQAL LYVILCPVGS YFPGDSMTPV SLLADPSFVR AWIGGVGDCK LGGNYGPTVA 240
VQREAQKRGC EQVLWLYGPD HQLTEVGTMN IFVYWTHEDG VLELVTPPLN GVILPGVVRQ 300
SLLDLARTWG EFRVAERKVT MKELKRALEE GRVREVFGSG TACQVCPVHQ ILYEGKQLHI 360
PTMENGPELI LRFQKELKAI QYGASAHDWM FRV 393 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0004084; F:branched-chain-amino-acid transaminase activity; IDA:MGI.
 GO:0052656; F:L-isoleucine transaminase activity; IEA:EC.
 GO:0052654; F:L-leucine transaminase activity; IEA:EC.
 GO:0052655; F:L-valine transaminase activity; IEA:EC.
 GO:0009082; P:branched-chain amino acid biosynthetic process; IEA:UniProtKB-KW.
 GO:0006550; P:isoleucine catabolic process; IMP:MGI.
 GO:0006551; P:leucine metabolic process; IMP:MGI.
 GO:0010817; P:regulation of hormone levels; IMP:MGI.
 GO:0006573; P:valine metabolic process; IMP:MGI. 
Interpro
 IPR001544; Aminotrans_IV.
 IPR018300; Aminotrans_IV_CS.
 IPR005786; B_amino_transII. 
Pfam
 PF01063; Aminotran_4 
SMART
  
PROSITE
 PS00770; AA_TRANSFER_CLASS_4 
PRINTS