CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015388
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Dynamin-binding protein 
Protein Synonyms/Alias
 Scaffold protein Tuba 
Gene Name
 Dnmbp 
Gene Synonyms/Alias
 Kiaa1010 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
721LNLLLEEKQDDPSRAubiquitination[1]
971NVNINEYKRRKDLVLacetylation[2]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758] 
Functional Description
 Scaffold protein that links dynamin with actin- regulating proteins. May play a role in membrane trafficking between the cell surface and the Golgi. 
Sequence Annotation
 DOMAIN 2 61 SH3 1.
 DOMAIN 66 127 SH3 2.
 DOMAIN 146 205 SH3 3.
 DOMAIN 244 303 SH3 4.
 DOMAIN 783 970 DH.
 DOMAIN 1011 1220 BAR.
 DOMAIN 1288 1351 SH3 5.
 DOMAIN 1516 1579 SH3 6.  
Keyword
 Alternative splicing; Cell junction; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Golgi apparatus; Reference proteome; Repeat; SH3 domain; Synapse. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1580 AA 
Protein Sequence
MEPGSMVRAI FDFCPSVSEE LPLFVGDVIE VLAVVDEFWL LGKKEDVTGQ FPSSFVEIVT 60
IPSLKEGERL FVCICEFVSR ELNSLSLHRG DLVILDDSAP TAGWLQGRSC WGAWGFFPSS 120
CVQELCLSSR SRRWHAQSAL LQAPEYSLGQ ARALMGLSAQ LDEELDFREG DLITIIGVPE 180
PGWFEGELEG RRGIFPEGFV ELLGPLRTVD ESVNSRSGDD SAVNGEVDVP PEEAESGGDE 240
DDQQSGTYGI ALYRFQALET NELDFEVGDR IQILGTLEDG WLEGCLKGKT GVFPHRFVKL 300
CPSNRTEETT AQPQESSFPK DSESSVGKSG DSVVEEARQE PWECEEERPD YDLPGQASVP 360
QDHVAPEWTG DTISGQDKDA SGSSPDVDLE RPLAKDLSTP DPSEEVNGVS SQPQVPIHPK 420
VQKSQHYLTA GGSHQTSDPF SELVPLEART RDYSSLPPRR TYAQGWSFQK PASHLQRASS 480
LTASRLDRPS HFCHPAMASY AQKHQTSTEN TASLHDPPER PERRPGLQDR GPATDITTAS 540
QGDSLDLDSK LTQQLIEFEK SLSGPSTEPE TIVRRFSIMD FYSEKDIVRG SSNSLPSQAF 600
PERRKTLRPP PPRPRTPTPI SSHLLVDQSP KPVPTLVVRP SRPAPLPPPA QQRMNTASPK 660
PTSCAHPGWE APEKEDSEHM EKSPAQTFPC PSMLARIRDV EQDLDTCTRA QEELNLLLEE 720
KQDDPSRAET LETLRSYEST IQSLTLELQQ LRDMTLLSSQ SSSLAAPFGS VSTENPEQRM 780
LEKRAKVVAE LLQTERDYIR DLEMCIERVM VPLQQAQVPN VDFEGLFGNM QTVIKVSKQL 840
LAALEISDAV GMSSCDCLVP GPVFLDHRDE LEGTYRVYCQ NHDEAISLLE MYEKDEKTQK 900
HLQDYLADLK GCTNYINLGS FLIKPVQRIM RYPLLLMELL NSTPESHPDK VPLTNAVLAV 960
KEINVNINEY KRRKDLVLKY RKGDEDSLME KISKLNIHSI IKKSSRVSSH LKHLTGFAPQ 1020
LKDEVFEETE KNFRMQERLI KSFIRDLSLY LQHIRESACV KVVAAMSIWD LCMERGHHDL 1080
EQFEKVHRYI SDQLFTRFKE RTERLVINPL NQLLNMFTGP YKLVQKRFDK LLDFYNCTER 1140
AEKLKDKKTL EELQSARNNY EALNSQLLDE LPKFQQYAQS LFTNCIHGYA EAHCDFVQQA 1200
LEQLQPLLSL LKATDREGNL IAIFLEEHSR VLQQLQVFTF FPESLPAPRK PFERKTTDRQ 1260
SSRKTLLGMP SYMLQSEELR SSLLARYPPE KLFHVQRNFN AAQDLDVSLL EGDLVGVIKK 1320
KDPMGSQNRW LVDNGVTKGF VYSSFLKPYN PRCSHSDASV ASHSSTESEH SGSSPGCHRQ 1380
NSHSALTFNS NNMTVSFTSG LALTQPQDAS PLKDCAHETL AVSWNTGHPE TGPSTCSSDP 1440
GFSCQRRLGN PADGARDISQ PASTLRGCQR SSPHSEVVGY SVPGRNDQGS DSIKGSARVC 1500
QAPEDRDRGV GSSETEGNQV YFAIYTFKAR NPNELSVLAN QRLRIHEFKD VTGNTEWWLA 1560
EVNGRKGYVP SNYIRKTEYT 1580 
Gene Ontology
 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
 GO:0005795; C:Golgi stack; IEA:UniProtKB-SubCell.
 GO:0045202; C:synapse; IEA:UniProtKB-SubCell.
 GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
 GO:0035556; P:intracellular signal transduction; IEA:InterPro.
 GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. 
Interpro
 IPR027267; AH/BAR-dom.
 IPR004148; BAR_dom.
 IPR000219; DH-domain.
 IPR001331; GDS_CDC24_CS.
 IPR000108; p67phox.
 IPR011511; SH3_2.
 IPR001452; SH3_domain. 
Pfam
 PF03114; BAR
 PF00621; RhoGEF
 PF00018; SH3_1
 PF07653; SH3_2 
SMART
 SM00721; BAR
 SM00325; RhoGEF
 SM00326; SH3 
PROSITE
 PS51021; BAR
 PS00741; DH_1
 PS50010; DH_2
 PS50002; SH3 
PRINTS
 PR00499; P67PHOX.