UniProt Accession

 RSSA_HUMAN; P08865; P11085; P12030; Q16471; Q6IPD1; Q6IPD2; Q6NSD1; Q6NXQ8; Q86VC0 

Genbank Protein ID

 J03799; X15005; S37431; U43901; AF503367; BT007219; BC005391; BC008867; BC010418; BC013827; BC034537; BC050688; BC053370; BC062714; BC066941; BC068062; BC070263; BC071693; BC071968; BC071969; BC071970; BC073863; BC107567; X61156; U36484; M14199; AB007146 

Genbank Nucleotide ID

 AAA36161.1; CAA33112.1; AAB22299.1; AAC50652.1; AAM33304.1; AAP35883.1; AAH05391.1; AAH08867.1; AAH10418.1; AAH13827.1; AAH34537.1; AAH50688.1; AAH53370.1; AAH62714.1; AAH66941.1; AAH68062.1; AAH70263.1; AAH71693.1; AAH71968.1; AAH71969.1; AAH71970.1; AAH73863.1; AAI07568.1; CAA43469.1; AAC50313.1; AAA36165.1; BAA25812.1 

Protein Name

 40S ribosomal protein SA 

Protein Synonyms/Alias

 37 kDa laminin receptor precursor; 37LRP; 37/67 kDa laminin receptor; LRP/LR; 67 kDa laminin receptor; 67LR; Colon carcinoma laminin-binding protein; Laminin receptor 1; LamR; Laminin-binding protein precursor p40; LBP/p40; Multidrug resistance-associated protein MGr1-Ag; NEM/1CHD4 

Gene Name

 RPSA 

Gene Synonyms/Alias

 LAMBR; LAMR1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
11	ALDVLQMKEEDVLKF	ubiquitination	[1, 2]
40	QMEQYIYKRKSDGIY	ubiquitination	[2, 3]
42	EQYIYKRKSDGIYII	ubiquitination	[2]
52	GIYIINLKRTWEKLL	acetylation	[4]
52	GIYIINLKRTWEKLL	ubiquitination	[2, 5, 6]
57	NLKRTWEKLLLAARA	ubiquitination	[2, 5]
89	TGQRAVLKFAAATGA	ubiquitination	[2, 3, 6]

Reference

 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [4] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [5] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [6] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 

Functional Description

 Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. 

Sequence Annotation

 REPEAT 230 232 [DE]-W-[ST] 1.
 REPEAT 247 249 [DE]-W-[ST] 2.
 REPEAT 266 268 [DE]-W-[ST] 3.
 REPEAT 275 277 [DE]-W-[ST] 4.
 REPEAT 293 295 [DE]-W-[ST] 5.
 REGION 54 113 Interaction with PPP1R16B.
 REGION 161 180 Laminin-binding.
 REGION 205 229 Laminin-binding.
 REGION 242 295 Laminin-binding.
 MOD_RES 2 2 N-acetylserine.
 MOD_RES 43 43 Phosphoserine (By similarity).
 MOD_RES 52 52 N6-acetyllysine.
 MOD_RES 139 139 Phosphotyrosine.
 MOD_RES 241 241 Phosphothreonine.  

Keyword

 3D-structure; Acetylation; Cell membrane; Complete proteome; Cytoplasm; Direct protein sequencing; Membrane; Nucleus; Phosphoprotein; Polymorphism; Receptor; Reference proteome; Repeat; Ribonucleoprotein; Ribosomal protein. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 295 AA 

Protein Sequence

Gene Ontology

 GO:0030686; C:90S preribosome; IBA:RefGenome.
 GO:0022627; C:cytosolic small ribosomal subunit; IDA:UniProtKB.
 GO:0005634; C:nucleus; TAS:UniProtKB.
 GO:0005886; C:plasma membrane; IDA:UniProtKB.
 GO:0005055; F:laminin receptor activity; IEA:HAMAP.
 GO:0043022; F:ribosome binding; IPI:UniProtKB.
 GO:0003735; F:structural constituent of ribosome; IBA:RefGenome.
 GO:0007155; P:cell adhesion; NAS:ProtInc.
 GO:0000447; P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:RefGenome.
 GO:0000461; P:endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:RefGenome.
 GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; TAS:Reactome.
 GO:0000028; P:ribosomal small subunit assembly; IBA:RefGenome.
 GO:0006407; P:rRNA export from nucleus; IBA:RefGenome.
 GO:0006614; P:SRP-dependent cotranslational protein targeting to membrane; TAS:Reactome.
 GO:0006414; P:translational elongation; TAS:Reactome.
 GO:0006413; P:translational initiation; TAS:Reactome.
 GO:0006415; P:translational termination; TAS:Reactome.
 GO:0019083; P:viral transcription; TAS:Reactome. 

Interpro

 IPR027504; 40S_ribosomal_SA.
 IPR001865; Ribosomal_S2.
 IPR018130; Ribosomal_S2_CS.
 IPR027498; Ribosomal_S2_euk.
 IPR005707; Ribosomal_S2_euk/arc.
 IPR023591; Ribosomal_S2_flav_dom. 

Pfam

 PF00318; Ribosomal_S2 

SMART

  

PROSITE

 PS00962; RIBOSOMAL_S2_1
 PS00963; RIBOSOMAL_S2_2 

PRINTS

 PR00395; RIBOSOMALS2.