UniProt Accession

 C5HTZ1_HUMAN; C5HTZ1 

Genbank Protein ID

 AC005840; AC006057; FJ515830 

Genbank Nucleotide ID

 ACS13722.1 

Protein Name

 Amiloride-sensitive sodium channel subunit alpha 

Protein Synonyms/Alias

 Amiloride-sensitive sodium channel subunit alpha 3 

Gene Name

 SCNN1A 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
22	QSTPGLMKGNKREEQ	ubiquitination	[1]
144	PYRYPEIKEELEELD	ubiquitination	[2]
220	NNPQVDWKDWKIGFQ	ubiquitination	[1, 2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Ion channel; Ion transport; Membrane; Reference proteome; Sodium; Sodium channel; Sodium transport; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 245 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005272; F:sodium channel activity; IEA:UniProtKB-KW.
 GO:0035725; P:sodium ion transmembrane transport; IEA:GOC. 

Interpro

 IPR001873; Na+channel_ASC. 

Pfam

 PF00858; ASC 

SMART

  

PROSITE

  

PRINTS

 PR01078; AMINACHANNEL.