UniProt Accession

 SMD2_MOUSE; P62317; P43330 

Genbank Protein ID

 AK007389; AK045968; AK088105; BC043014; BC051208 

Genbank Nucleotide ID

 BAB25006.1; BAC32551.1; BAC40147.1; AAH43014.1; AAH51208.1 

Protein Name

 Small nuclear ribonucleoprotein Sm D2 

Protein Synonyms/Alias

 Sm-D2; snRNP core protein D2 

Gene Name

 Snrpd2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
8	MSLLNKPKSEMTPEE	ubiquitination	[1]
98	NKDRYISKMFLRGDS	acetylation	[2]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

 Required for pre-mRNA splicing. Required for snRNP biogenesis (By similarity). 

Sequence Annotation

 MOD_RES 2 2 N-acetylserine (By similarity).
 MOD_RES 12 12 Phosphothreonine (By similarity).  

Keyword

 3D-structure; Acetylation; Complete proteome; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Reference proteome; Ribonucleoprotein; Spliceosome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 118 AA 

Protein Sequence

Gene Ontology

 GO:0071013; C:catalytic step 2 spliceosome; IEA:Compara.
 GO:0030532; C:small nuclear ribonucleoprotein complex; IEA:InterPro.
 GO:0005689; C:U12-type spliceosomal complex; IEA:Compara.
 GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
 GO:0008380; P:RNA splicing; IEA:UniProtKB-KW. 

Interpro

 IPR010920; LSM_dom.
 IPR001163; Ribonucl_LSM.
 IPR006649; Ribonucl_LSM_euk/arc.
 IPR027248; Sm_D2. 

Pfam

 PF01423; LSM 

SMART

 SM00651; Sm 

PROSITE

  

PRINTS