UniProt Accession

 PDCL3_HUMAN; Q9H2J4; B2RA00; Q53S68 

Genbank Protein ID

 AF110511; AF267853; AK313985; AC068538; CH471127; BC001021 

Genbank Nucleotide ID

 AAG21887.1; AAG44722.1; BAG36697.1; AAX93227.1; EAX01838.1; AAH01021.1 

Protein Name

 Phosducin-like protein 3 

Protein Synonyms/Alias

 HTPHLP; PhPL3; Viral IAP-associated factor 1; VIAF-1 

Gene Name

 PDCL3 

Gene Synonyms/Alias

 VIAF1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
83	RRRLAEWKATKLKNK	ubiquitination	[1]
90	KATKLKNKFGEVLEI	ubiquitination	[2, 3]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Modulates the activation of caspases during apoptosis. Is a substrate for Orgyia pseudotsugata multicapsid polyhedrosis virus (OpMNPV) IAP-mediated ubiquitination. 

Sequence Annotation

 MOD_RES 234 234 Phosphoserine.
 MOD_RES 236 236 Phosphoserine.  

Keyword

 Apoptosis; Complete proteome; Cytoplasm; Host-virus interaction; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 239 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
 GO:0019048; P:virus-host interaction; IEA:UniProtKB-KW. 

Interpro

 IPR006442; Antitoxin_Phd/YefM.
 IPR024253; Phosducin_thioredoxin-like_dom.
 IPR012336; Thioredoxin-like_fold. 

Pfam

 PF02114; Phosducin 

SMART

  

PROSITE

  

PRINTS