UniProt Accession

 B7Z3K3_HUMAN; B7Z3K3 

Genbank Protein ID

 AC008397; AK296022 

Genbank Nucleotide ID

 BAH12239.1 

Protein Name

 Inositol-3-phosphate synthase 1 

Protein Synonyms/Alias

 cDNA FLJ57998, highly similar to Homo sapiens myo-inositol 1-phosphate synthase A1 (ISYNA1), mRNA 

Gene Name

 ISYNA1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
20	RSSAGLDKVIVLWTA	ubiquitination	[1, 2, 3]
103	FVGGDDFKSGQTKVK	ubiquitination	[2, 3]
108	DFKSGQTKVKSVLVD	ubiquitination	[2]
110	KSGQTKVKSVLVDFL	ubiquitination	[1, 2, 3]
191	VPYVGDSKRALDEYT	ubiquitination	[2, 3]
328	ATYPMLNKKGPVPAA	ubiquitination	[1, 2, 3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 356 AA 

Protein Sequence

Gene Ontology

 GO:0004512; F:inositol-3-phosphate synthase activity; IEA:InterPro.
 GO:0006021; P:inositol biosynthetic process; IEA:InterPro.
 GO:0008654; P:phospholipid biosynthetic process; IEA:InterPro. 

Interpro

 IPR002587; Myo-inos-1-P_Synthase.
 IPR013021; Myo-inos-1-P_Synthase_GAPDH.
 IPR016040; NAD(P)-bd_dom. 

Pfam

 PF01658; Inos-1-P_synth
 PF07994; NAD_binding_5 

SMART

  

PROSITE

  

PRINTS