| Tag | Content |
|---|
| CPLM ID | CPLM-011341 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Sorting nexin-1 |
Protein Synonyms/Alias | |
Gene Name | SNX1 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Bos taurus (Bovine) |
NCBI Taxa ID | 9913 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 214 | IVPPPPEKSLIGMTK | ubiquitination | [1] | | 221 | KSLIGMTKVKVGKED | ubiquitination | [1] | | 223 | LIGMTKVKVGKEDSS | ubiquitination | [1] | | 267 | DVREFLEKEELPRAV | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | May be involved in several stages of intracellular trafficking. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi. Component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Interacts with membranes containing phosphatidylinositol 3- phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (By similarity). |
Sequence Annotation | DOMAIN 143 272 PX.
DOMAIN 302 522 BAR.
BINDING 186 186 Phosphatidylinositol 3-phosphate (By
BINDING 188 188 Phosphatidylinositol 3-phosphate; via
BINDING 214 214 Phosphatidylinositol 3-phosphate (By
BINDING 238 238 Phosphatidylinositol 3-phosphate (By
MOD_RES 32 32 Phosphoserine (By similarity).
MOD_RES 39 39 Phosphoserine (By similarity).
MOD_RES 188 188 Phosphoserine (By similarity).
MOD_RES 237 237 N6-acetyllysine (By similarity). |
Keyword | Acetylation; Complete proteome; Endosome; Golgi apparatus; Lipid-binding; Membrane; Phosphoprotein; Protein transport; Reference proteome; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 522 AA |
Protein Sequence | MASGGGGCSA SERLPPPFPG LEPESEGAVG GSEPEAGDSD TEGEDIFTGA AAVSKPQSPK 60
RIASLLPINS GSKENGIHEE QDQEPQDLFA DATVELSLDS TQNNQKKVPA KTLISLPPQE 120
ATNSSKPQPS YEELEEEEQE DQFDLTVGIT DPEKIGDGMN AYVAYKVTTQ TSLPMFRSKH 180
FAVKRRFSDF LGLYEKLSEK HSQNGFIVPP PPEKSLIGMT KVKVGKEDSS SAEFLEKRRA 240
ALERYLQRIV NHPTMLQDPD VREFLEKEEL PRAVGTQTLS GAGLLKMFNK ATDAVSKMTI 300
NMNESDIWFE EKLQEVECEE QRLRKLHAVV ETLVNHRKEL ALNTAQFAKS LAMLGSSEDN 360
TALSRALSQL AEVEEKIEQL HQEQANNDFF LLAELLSDYI RLLAIVRAAF DQRMKTWQRW 420
QDAQTTLQKK REAEARLLWA NKPDKLQQAK DEIVEWESRV TQYERDFERI STVVRKEVIR 480
FEKEKSRDFR NHVIQYLETL LHSQQQLAKY WEAFLPEAKA IS 522 |
Gene Ontology | GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell. GO:0010008; C:endosome membrane; ISS:UniProtKB. GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell. GO:0035091; F:phosphatidylinositol binding; ISS:UniProtKB. GO:0008565; F:protein transporter activity; IEA:InterPro. GO:0007154; P:cell communication; IEA:InterPro. GO:0006886; P:intracellular protein transport; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |