UniProt Accession

 K1C14_HUMAN; P02533; Q14715; Q53XY3; Q9BUE3; Q9UBN2; Q9UBN3; Q9UCY4 

Genbank Protein ID

 J00124; BT007186; AC019349; BC002690; BC019097; BC042437; BC094830; D28807; AF186085; AF186086; AF186087; AF186088; AF186089; AF186090 

Genbank Nucleotide ID

 AAB59562.1; AAP35850.1; AAH02690.1; AAH19097.1; AAH42437.1; AAH94830.1; BAA05967.1; AAF04034.1; AAF04035.1; AAF04036.1; AAF04037.1; AAF04038.1; AAF04039.1 

Protein Name

 Keratin, type I cytoskeletal 14 

Protein Synonyms/Alias

 Cytokeratin-14; CK-14; Keratin-14; K14 

Gene Name

 KRT14 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
132	RLASYLDKVRALEEA	acetylation	[1]
167	KDYSPYFKTIEDLRN	ubiquitination	[2]
243	EMQIESLKEELAYLK	methylation	[3]

Reference

 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] Large-scale global identification of protein lysine methylation in vivo.
 Cao XJ, Arnaudo AM, Garcia BA.
 Epigenetics. 2013 May 1;8(5):477-85. [PMID: 23644510] 

Functional Description

 The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro. 

Sequence Annotation

 REGION 1 114 Head.
 REGION 115 422 Rod.
 REGION 115 150 Coil 1A.
 REGION 151 168 Linker 1.
 REGION 169 260 Coil 1B.
 REGION 261 283 Linker 12.
 REGION 284 422 Coil 2.
 REGION 423 472 Tail.
 REGION 425 472 Interaction with Type I keratins and
 DISULFID 367 367 Interchain.  

Keyword

 3D-structure; Coiled coil; Complete proteome; Cytoplasm; Disease mutation; Disulfide bond; Ectodermal dysplasia; Epidermolysis bullosa; Intermediate filament; Keratin; Nucleus; Palmoplantar keratoderma; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 472 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0045095; C:keratin filament; IDA:MGI.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0005200; F:structural constituent of cytoskeleton; TAS:ProtInc.
 GO:0008544; P:epidermis development; TAS:ProtInc.
 GO:0031581; P:hemidesmosome assembly; TAS:Reactome.
 GO:0045110; P:intermediate filament bundle assembly; IMP:UniProtKB. 

Interpro

 IPR016044; F.
 IPR001664; IF.
 IPR018039; Intermediate_filament_CS.
 IPR002957; Keratin_I.
 IPR009053; Prefoldin. 

Pfam

 PF00038; Filament 

SMART

  

PROSITE

 PS00226; IF 

PRINTS

 PR01248; TYPE1KERATIN.