| Tag | Content |
|---|
| CPLM ID | CPLM-012805 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | ATP-dependent RNA helicase WM6 |
Protein Synonyms/Alias | DEAD box protein UAP56; Dmrnahel; HEL/UAP56 |
Gene Name | Hel25E |
Gene Synonyms/Alias | Dbp25F; hel; WM6; CG7269 |
Created Date | July 27, 2013 |
Organism | Drosophila melanogaster (Fruit fly) |
NCBI Taxa ID | 7227 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 135 | KEYERFSKYMPTVKV | acetylation | [1] | | 185 | RNKKLNLKLLKHFVL | acetylation | [1] |
|
Reference | [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation. Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C. Sci Signal. 2011 Jul 26;4(183):ra48. [ PMID: 21791702] |
Functional Description | Required for mRNA export out of the nucleus. Probable RNA helicase that may regulate entry into mitosis by down- regulating the expression of other genes whose activity may be rate-limiting for entry into mitosis during embryogenesis. Binds to salivary gland chromosomes and modifies position effect variegation. Promotes an open chromatin structure that favors transcription during development by regulating the spread of heterochromatin. |
Sequence Annotation | DOMAIN 72 246 Helicase ATP-binding.
DOMAIN 258 419 Helicase C-terminal.
NP_BIND 85 92 ATP (By similarity).
MOTIF 41 69 Q motif.
MOTIF 193 196 DECD box. |
Keyword | ATP-binding; Complete proteome; Helicase; Hydrolase; mRNA processing; mRNA splicing; Nucleotide-binding; Nucleus; Reference proteome; RNA-binding; Spliceosome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 424 AA |
Protein Sequence | MADNDDLLDY EDEEQTETTA VENQEAPKKD VKGTYVSIHS SGFRDFLLKP EILRAIVDCG 60
FEHPSEVQHE CIPQAVLGMD ILCQAKSGMG KTAVFVLATL QQLEPSDNNT CHVLVMCHTR 120
ELAFQISKEY ERFSKYMPTV KVAVFFGGMA IQKDEETLKS GTPHIVVGTP GRILALIRNK 180
KLNLKLLKHF VLDECDKMLE QLDMRRDVQE IFRSTPHGKQ VMMFSATLSK DIRPVCKKFM 240
QDPMEVYVDD EAKLTLHGLQ QHYVNLKENE KNKKLFELLD VLEFNQVVIF VKSVQRCVAL 300
SQLLTEQNFP AIGIHRGMTQ EERLNRYQQF KDFQKRILVA TNLFGRGMDI ERVNIVFNYD 360
MPEDSDTYLH RVARAGRFGT KGLAITFVSD ENDAKILNEV QDRFDVNISE LPEEIDLSTY 420
IEGR 424 |
Gene Ontology | GO:0005875; C:microtubule associated complex; IDA:FlyBase. GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell. GO:0005681; C:spliceosomal complex; ISS:FlyBase. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0004004; F:ATP-dependent RNA helicase activity; ISS:FlyBase. GO:0003723; F:RNA binding; IEA:UniProtKB-KW. GO:0006338; P:chromatin remodeling; IMP:FlyBase. GO:0007052; P:mitotic spindle organization; IMP:FlyBase. GO:0006406; P:mRNA export from nucleus; IMP:FlyBase. GO:0000398; P:mRNA splicing, via spliceosome; ISS:FlyBase. GO:0000381; P:regulation of alternative mRNA splicing, via spliceosome; IMP:FlyBase. |
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PROSITE | |
PRINTS | |