Tag | Content |
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CPLM ID | CPLM-018235 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Apoptosis-enhancing nuclease |
Protein Synonyms/Alias | Interferon-stimulated 20 kDa exonuclease-like 1 |
Gene Name | AEN |
Gene Synonyms/Alias | ISG20L1; SBBI58 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
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101 | SRRPAPGKASGPLPS | ubiquitination | [1] | 109 | ASGPLPSKCVAIDCE | ubiquitination | [1] |
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Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Exonuclease with activity against single- and double- stranded DNA and RNA. Mediates p53-induced apoptosis. When induced by p53 following DNA damage, digests double-stranded DNA to form single-stranded DNA and amplifies DNA damage signals, leading to enhancement of apoptosis. |
Sequence Annotation | DOMAIN 110 266 Exonuclease. MOTIF 27 35 Nucleolar localization signal. MOTIF 165 188 Nuclear localization signal. |
Keyword | Alternative splicing; Apoptosis; Complete proteome; DNA damage; Exonuclease; Hydrolase; Nuclease; Nucleus; Polymorphism; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 325 AA |
Protein Sequence | MVPREAPESA QCLCPSLTIP NAKDVLRKRH KRRSRQHQRF MARKALLQEQ GLLSMPPEPG 60 SSPLPTPFGA ATATEAASSG KQCLRAGSGS APCSRRPAPG KASGPLPSKC VAIDCEMVGT 120 GPRGRVSELA RCSIVSYHGN VLYDKYIRPE MPIADYRTRW SGITRQHMRK AVPFQVAQKE 180 ILKLLKGKVV VGHALHNDFQ ALKYVHPRSQ TRDTTYVPNF LSEPGLHTRA RVSLKDLALQ 240 LLHKKIQVGQ HGHSSVEDAT TAMELYRLVE VQWEQQEARS LWTCPEDREP DSSTDMEQYM 300 EDQSTQYWAL KQKSEKQDSG LNSGAFV 327 |
Gene Ontology | GO:0005730; C:nucleolus; IDA:UniProtKB. GO:0005654; C:nucleoplasm; IDA:UniProtKB. GO:0004527; F:exonuclease activity; IDA:UniProtKB. GO:0003676; F:nucleic acid binding; IEA:InterPro. GO:0042771; P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; IDA:UniProtKB. GO:0010212; P:response to ionizing radiation; IDA:UniProtKB. |
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