UniProt Accession

 SELPL_HUMAN; Q14242; A8K2Y0; B4DQC3; B7Z5C7; J3KMX6; Q12775; Q6GTW7; Q8N7J7 

Genbank Protein ID

 U25956; U02297; AK098315; AK290395; AK298738; AK298742; AY331789; AC007569; AC008119; BC029782 

Genbank Nucleotide ID

 AAA74577.1; AAC50061.1; BAC05283.1; BAF83084.1; BAG60885.1; BAH12863.1; AAP81163.1; AAH29782.1 

Protein Name

 P-selectin glycoprotein ligand 1 

Protein Synonyms/Alias

 PSGL-1; Selectin P ligand; CD162 

Gene Name

 SELPLG 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
388	NGGLSKAKSPGLTPE	ubiquitination	[1, 2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 A SLe(x)-type glycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. PSGL1 is critical for the initial leukocyte capture. 

Sequence Annotation

 REPEAT 122 131 1.
 REPEAT 132 141 2.
 REPEAT 142 151 3.
 REPEAT 162 171 4.
 REPEAT 182 191 5.
 REPEAT 192 201 6.
 REPEAT 202 211 7.
 REPEAT 212 221 8.
 REPEAT 222 231 9.
 REPEAT 232 241 10.
 REPEAT 242 251 11.
 REPEAT 252 261 12.
 REGION 122 261 12 X 10 AA tandem repeats.
 MOD_RES 42 42 Pyrrolidone carboxylic acid.
 MOD_RES 46 46 Sulfotyrosine.
 MOD_RES 48 48 Sulfotyrosine.
 MOD_RES 51 51 Sulfotyrosine.
 CARBOHYD 57 57 O-linked (GalNAc...).
 CARBOHYD 65 65 N-linked (GlcNAc...) (Potential).
 CARBOHYD 111 111 N-linked (GlcNAc...) (Potential).
 CARBOHYD 302 302 N-linked (GlcNAc...) (Potential).
 DISULFID 320 320 Interchain.  

Keyword

 3D-structure; Alternative splicing; Cell adhesion; Cleavage on pair of basic residues; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Membrane; Polymorphism; Pyrrolidone carboxylic acid; Reference proteome; Repeat; Sialic acid; Signal; Sulfation; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 412 AA 

Protein Sequence

Gene Ontology

 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0005102; F:receptor binding; NAS:ProtInc.
 GO:0007596; P:blood coagulation; TAS:Reactome.
 GO:0007155; P:cell adhesion; TAS:ProtInc.
 GO:0071354; P:cellular response to interleukin-6; IDA:MGI.
 GO:0050902; P:leukocyte adhesive activation; ISS:UniProtKB.
 GO:0050901; P:leukocyte tethering or rolling; IEA:Compara. 

Interpro

 IPR026195; PSGL-1. 

Pfam

  

SMART

  

PROSITE

  

PRINTS