CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-035787
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Paired box gene 2 (Predicted) 
Protein Synonyms/Alias
 Protein Pax2 
Gene Name
 Pax2 
Gene Synonyms/Alias
 Pax2_predicted; rCG_57597 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
78YYETGSIKPGVIGGSacetylation[1]
97ATPKVVDKIAEYKRQacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Developmental protein; DNA-binding; Nucleus; Paired box; Reference proteome; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 416 AA 
Protein Sequence
MDMHCKADPF SAMHRHGGVN QLGGVFVNGR PLPDVVRQRI VELAHQGVRP CDISRQLRVS 60
HGCVSKILGR YYETGSIKPG VIGGSKPKVA TPKVVDKIAE YKRQNPTMFA WEIRDRLLAE 120
GICDNDTVPS VSSINRIIRT KVQQPFHPTP DGAGTGVTAP GHTIVPSTAS PPVSSASNDP 180
VGSYSINGIL GIPRSNGEKR KREEVEVYTD PAHIRGGGGL HLVWTLRDVS EGSVPNGDSQ 240
SGVDSLRKHL RADTFTQQQL EALDRVFERP SYPDVFQASE HIKSEQGNEY SLPALTPGLD 300
EVKSSLSAST NPELGSNVSG TQTYPVVTGR DMASTTLPGY PPHVPPTGQG SYPTSTLAGM 360
VPGSEFSGNP YSHPQYTAYN EAWRFSNPAL LSSPYYYSAA PRGSAPAAAA AAYDRH 416 
Gene Ontology
 GO:0034451; C:centriolar satellite; ISS:UniProtKB.
 GO:0005764; C:lysosome; IDA:RGD.
 GO:0005634; C:nucleus; ISS:UniProtKB.
 GO:0043234; C:protein complex; ISS:UniProtKB.
 GO:0032993; C:protein-DNA complex; ISS:UniProtKB.
 GO:0000987; F:core promoter proximal region sequence-specific DNA binding; ISS:UniProtKB.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IC:RGD.
 GO:0016175; F:superoxide-generating NADPH oxidase activity; ISS:UniProtKB.
 GO:0007568; P:aging; IEP:RGD.
 GO:0048854; P:brain morphogenesis; ISS:UniProtKB.
 GO:0001658; P:branching involved in ureteric bud morphogenesis; ISS:UniProtKB.
 GO:0001709; P:cell fate determination; ISS:UniProtKB.
 GO:0071364; P:cellular response to epidermal growth factor stimulus; IEP:RGD.
 GO:0071333; P:cellular response to glucose stimulus; ISS:UniProtKB.
 GO:0070301; P:cellular response to hydrogen peroxide; ISS:UniProtKB.
 GO:0071260; P:cellular response to mechanical stimulus; IEA:Compara.
 GO:0071300; P:cellular response to retinoic acid; ISS:UniProtKB.
 GO:0090103; P:cochlea morphogenesis; ISS:UniProtKB.
 GO:0010001; P:glial cell differentiation; ISS:UniProtKB.
 GO:0003337; P:mesenchymal to epithelial transition involved in metanephros morphogenesis; ISS:UniProtKB.
 GO:0007501; P:mesodermal cell fate specification; ISS:UniProtKB.
 GO:0072177; P:mesonephric duct development; IEA:Compara.
 GO:0072172; P:mesonephric tubule formation; IEA:Compara.
 GO:0001823; P:mesonephros development; ISS:UniProtKB.
 GO:0072205; P:metanephric collecting duct development; ISS:UniProtKB.
 GO:0072221; P:metanephric distal convoluted tubule development; ISS:UniProtKB.
 GO:0072162; P:metanephric mesenchymal cell differentiation; ISS:UniProtKB.
 GO:0072289; P:metanephric nephron tubule formation; ISS:UniProtKB.
 GO:1900215; P:negative regulation of apoptotic process involved in metanephric collecting duct development; ISS:UniProtKB.
 GO:1900218; P:negative regulation of apoptotic process involved in metanephric nephron tubule development; ISS:UniProtKB.
 GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; ISS:UniProtKB.
 GO:0045918; P:negative regulation of cytolysis; ISS:UniProtKB.
 GO:0072305; P:negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis; ISS:UniProtKB.
 GO:2000378; P:negative regulation of reactive oxygen species metabolic process; ISS:UniProtKB.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; ISS:UniProtKB.
 GO:0072179; P:nephric duct formation; ISS:UniProtKB.
 GO:0001843; P:neural tube closure; ISS:UniProtKB.
 GO:0061360; P:optic chiasma development; ISS:UniProtKB.
 GO:0002072; P:optic cup morphogenesis involved in camera-type eye development; ISS:UniProtKB.
 GO:0021633; P:optic nerve structural organization; ISS:UniProtKB.
 GO:0031016; P:pancreas development; IEA:Compara.
 GO:0061205; P:paramesonephric duct development; IEA:Compara.
 GO:0090190; P:positive regulation of branching involved in ureteric bud morphogenesis; ISS:UniProtKB.
 GO:0008284; P:positive regulation of cell proliferation; IMP:RGD.
 GO:0050679; P:positive regulation of epithelial cell proliferation; IEA:Compara.
 GO:0072108; P:positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis; ISS:UniProtKB.
 GO:2000594; P:positive regulation of metanephric DCT cell differentiation; ISS:UniProtKB.
 GO:0072300; P:positive regulation of metanephric glomerulus development; ISS:UniProtKB.
 GO:2000597; P:positive regulation of optic nerve formation; ISS:UniProtKB.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.
 GO:0039003; P:pronephric field specification; ISS:UniProtKB.
 GO:0043491; P:protein kinase B signaling cascade; ISS:UniProtKB.
 GO:0072593; P:reactive oxygen species metabolic process; ISS:UniProtKB.
 GO:0072307; P:regulation of metanephric nephron tubule epithelial cell differentiation; ISS:UniProtKB.
 GO:0035566; P:regulation of metanephros size; ISS:UniProtKB.
 GO:0031667; P:response to nutrient levels; IEP:RGD.
 GO:0003406; P:retinal pigment epithelium development; ISS:UniProtKB.
 GO:0006351; P:transcription, DNA-dependent; ISS:UniProtKB.
 GO:0035799; P:ureter maturation; ISS:UniProtKB.
 GO:0072197; P:ureter morphogenesis; IEA:Compara.
 GO:0021650; P:vestibulocochlear nerve formation; ISS:UniProtKB. 
Interpro
 IPR009057; Homeodomain-like.
 IPR001523; Paired_dom.
 IPR022130; Pax2_C.
 IPR011991; WHTH_DNA-bd_dom. 
Pfam
 PF00292; PAX
 PF12403; Pax2_C 
SMART
 SM00351; PAX 
PROSITE
 PS00034; PAIRED_1
 PS51057; PAIRED_2 
PRINTS
 PR00027; PAIREDBOX.