Tag | Content |
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CPLM ID | CPLM-024128 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Heterogeneous nuclear ribonucleoproteins C1/C2 |
Protein Synonyms/Alias | hnRNP C1/C2 |
Gene Name | Hnrnpc |
Gene Synonyms/Alias | Hnrpc |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
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29 | NLNTLVVKKSDVEAI | ubiquitination | [1] | 39 | DVEAIFSKYGKIVGC | ubiquitination | [1] | 89 | INLAAEPKVNRGKAG | ubiquitination | [1] | 177 | SSKSGKLKGDDLQAI | ubiquitination | [1] | 186 | DDLQAIKKELTQIKQ | ubiquitination | [1] | 194 | ELTQIKQKVDSLLES | ubiquitination | [1] | 204 | SLLESLEKIEKEQSK | ubiquitination | [1] | 211 | KIEKEQSKQADLSFS | ubiquitination | [1] | 224 | FSSPVEMKNEKSEEE | ubiquitination | [1] |
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Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles. Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides. May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules (By similarity). |
Sequence Annotation | DOMAIN 16 87 RRM. MOTIF 155 161 Nuclear localization signal (Potential). MOD_RES 2 2 N-acetylalanine (By similarity). MOD_RES 39 39 N6-acetyllysine (By similarity). MOD_RES 107 107 Phosphoserine (By similarity). MOD_RES 113 113 Phosphoserine (By similarity). MOD_RES 115 115 Phosphoserine (By similarity). MOD_RES 120 120 Phosphoserine (By similarity). MOD_RES 121 121 Phosphoserine (By similarity). MOD_RES 138 138 Phosphoserine (By similarity). MOD_RES 162 162 Phosphoserine (By similarity). MOD_RES 170 170 N6-acetyllysine (By similarity). MOD_RES 217 217 N6-acetyllysine (By similarity). MOD_RES 232 232 Phosphoserine. MOD_RES 241 241 Phosphoserine. MOD_RES 246 246 Phosphoserine (By similarity). MOD_RES 247 247 Phosphoserine (By similarity). MOD_RES 249 249 Phosphoserine. MOD_RES 268 268 Phosphoserine. MOD_RES 306 306 Phosphoserine (By similarity). MOD_RES 313 313 Phosphoserine (By similarity). CROSSLNK 258 258 Glycyl lysine isopeptide (Lys-Gly) |
Keyword | Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; Isopeptide bond; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Reference proteome; Ribonucleoprotein; RNA-binding; Spliceosome; Ubl conjugation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 313 AA |
Protein Sequence | MASNVTNKTD PRSMNSRVFI GNLNTLVVKK SDVEAIFSKY GKIVGCSVHK GFAFVQYVNE 60 RNARAAVAGE DGRMIAGQVL DINLAAEPKV NRGKAGVKRS AAEMYGSSFD LDYDFQRDYY 120 DRMYSYPARV PPPPPIARAV VPSKRQRVSG NTSRRGKSGF NSKSGQRGSS SKSGKLKGDD 180 LQAIKKELTQ IKQKVDSLLE SLEKIEKEQS KQADLSFSSP VEMKNEKSEE EQSSASVKKD 240 ETNVKMESEA GADDSAEEGD LLDDDDNEDR GDDQLELKDD EKEPEEGEDD RDSANGEDDS 300 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |