CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041091
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Glyceraldehyde-3-phosphate dehydrogenase 
Protein Synonyms/Alias
  
Gene Name
 Gapdh 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
59GKFNGTVKAENGKLVacetylation[1]
70GKLVINGKPITIFQEacetylation[1, 2]
70GKLVINGKPITIFQEubiquitination[3]
84ERDPTNIKWGEAGAEubiquitination[3]
105GVFTTMEKAGAHLKGacetylation[2, 4]
105GVFTTMEKAGAHLKGsuccinylation[2]
105GVFTTMEKAGAHLKGubiquitination[3]
218DLTCRLEKPAKYDDIubiquitination[3]
Reference
 [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [4] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 302 AA 
Protein Sequence
MVKVGVNGFG RIGRLVTRAA ICSGKVEIVA INDPFIDLNY MVYMFQYDST HGKFNGTVKA 60
ENGKLVINGK PITIFQERDP TNIKWGEAGA EYVVESTGVF TTMEKAGAHL KGGAKRVIIS 120
APSADAPMFV IHDNFGIVEG LMTTVHAITA TQKTVDGPSG KLWRDGRGAA QNIIPASTGA 180
AKAVGKVIPE LNGKLTGMAF RVPTPNVSVV DLTCRLEKPA KYDDIKKVVK QASEGPLKGI 240
LGYTEDQVVS CDFNSNSHSS TFDAGAGIAL NDNFVKLISW YDNEYGYSNR VVDLMAYMAS 300
KE 302 
Gene Ontology
 GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro. 
Interpro
 IPR020831; GlycerAld/Erythrose_P_DH.
 IPR020829; GlycerAld_3-P_DH_cat.
 IPR020828; GlycerAld_3-P_DH_NAD(P)-bd.
 IPR016040; NAD(P)-bd_dom. 
Pfam
 PF02800; Gp_dh_C
 PF00044; Gp_dh_N 
SMART
 SM00846; Gp_dh_N 
PROSITE
  
PRINTS