CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-044365
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Nuclear pore complex protein Nup98-Nup96 
Protein Synonyms/Alias
  
Gene Name
 NUP98 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
193HQCITAMKEYESKSLubiquitination[1, 2]
198AMKEYESKSLEELRLubiquitination[1, 2]
622ERFSFLSKPVDENHQubiquitination[1, 2, 3, 4]
648FYTNPIAKPIPQTPEubiquitination[3, 4, 5]
735PSMDDLAKITNEKGEubiquitination[3]
740LAKITNEKGECIVSDubiquitination[1, 2, 5, 6]
801VGEGLNRKAEVTLDGubiquitination[1, 3]
814DGVWPTDKTSRCLIKubiquitination[1, 2, 4]
821KTSRCLIKSPDRLADubiquitination[1]
908LQMALNGKPAPPPQSubiquitination[3]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [5] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [6] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1638 AA 
Protein Sequence
MFNKSFGTPF GGGTGGFGTT STFGQNTGFG TTSGGAFGTS AFGSSNNTGG LFGNSQTKPG 60
GLFGTSSFSQ PATSTSTGFG FGTSTGTANT LFGTASTGTS LFSSQNNAFA QNKPTGFGNF 120
GTSTSSGGLF GTTNTTSNPF GSTSGSLFGP SSFTAAPTGT TIKFNPPTGT DTMVKAGVST 180
NISTKHQCIT AMKEYESKSL EELRLEDYQA NRKGPQNQVG AGTTTGLFGS SPATSSATGL 240
FSSSTTNSGF AYGQNKTAFG TSTTGFGTNP GGLFGQQNQQ TTSLFSKPFG QATTTQNTGF 300
SFGNTSTIGQ PSTNTMGLFG VTQASQPGGL FGTATNTSTG TAFGTGTGLF GQTNTGFGAV 360
GSTLFGNNKL TTFGSSTTSA PSFGTTSGGL FGFGTNTSGN SIFGSKPAPG TLGTGLGAGF 420
GTALGAGQAS LFGNNQPKIG GPLGTGAFGA PGFNTTTATL GFGAPQAPVA LTDPNASAAQ 480
QAVLQQHINS LTYSPFGDSP LFRNPMSDPK KKEERLKPTN PAAQKALTTP THYKLTPRPA 540
TRVRPKALQT TGTAKSHLFD GLDDDEPSLA NGAFMPKKSI KKLVLKNLNN SNLFSPVNRD 600
SENLASPSEY PENGERFSFL SKPVDENHQQ DGDEDSLVSH FYTNPIAKPI PQTPESAGNK 660
HSNSNSVDDT IVALNMRAAL RNGLEGSSEE TSFHDESLQD DREEIENNSY HMHPAGIILT 720
KVGYYTIPSM DDLAKITNEK GECIVSDFTI GRKGYGSIYF EGDVNLTNLN LDDIVHIRRK 780
EVVVYLDDNQ KPPVGEGLNR KAEVTLDGVW PTDKTSRCLI KSPDRLADIN YEGRLEAVSR 840
KQGAQFKEYR PETGSWVFKV SHFSKYGLQD SDEEEEEHPS KTSTKKLKTA PLPPASQTTP 900
LQMALNGKPA PPPQSQSPEV EQLGRVVELD SDMVDITQEP VLDTMLEESM PEDQEPVSAS 960
THIASSLGIN PHVLQIMKAS LLTDEEDVDM ALDQRFSRLP SKADTSQEIC SPRLPISASH 1020
SSKTRSLVGG LLQSKFTSGA FLSPSVSVQE CRTPRAASLM NIPSTSSWSV PPPLTSVFTM 1080
PSPAPEVPLK TVGTRRQLGL VPREKSVTYG KGKLLMDMAL FMGRSFRVGW GPNWTLANSG 1140
EQLNGSHELE NHQIADSMEF GFLPNPVAVK PLTESPFKVH LEKLSLRQRK PDEDMKLYQT 1200
PLELKLKHST VHVDELCPLI VPNLGVAVIH DYADWVKEAS GDLPEAQIVK HWSLTWTLCE 1260
ALWGHLKELD SQLNEPREYI QILERRRAFS RWLSCTATPQ IEEEVSLTQK NSPVEAVFSY 1320
LTGKRISEAC SLAQQSGDHR LALLLSQFVG SQSVRELLTM QLVDWHQLQA DSFIQDERLR 1380
IFALLAGKPV WQLSEKKQIN VCSQLDWKRS LAIHLWYLLP PTASISRALS MYEEAFQNTS 1440
DSDRYACSPL PSYLEGSGCV IAEEQNSQTP LRDVCFHLLK LYSDSIREKA VRELLTRHCQ 1500
LLETPESWAK ETFLTQKLRV PAKWIHEAKA VRAHMESDKH LEALCLFKAE HWNRCHKLII 1560
RHLASDAIIN ENYDYLKGFL EDLAPPERSS LIQDWETSGL VYLDYIRVIE MLRHIQQIAL 1620
FCVEWIAQVM TWSSYTSK 1638 
Gene Ontology
 GO:0005643; C:nuclear pore; IEA:InterPro.
 GO:0006810; P:transport; IEA:InterPro. 
Interpro
 IPR021967; Nup96.
 IPR007230; Peptidase_S59. 
Pfam
 PF04096; Nucleoporin2
 PF12110; Nup96 
SMART
  
PROSITE
 PS51434; NUP_C 
PRINTS