| Tag | Content |
|---|
| CPLM ID | CPLM-008347 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Sodium/potassium-transporting ATPase subunit alpha-1 |
Protein Synonyms/Alias | Na(+)/K(+) ATPase alpha-1 subunit; Sodium pump subunit alpha-1 |
Gene Name | ATP1A1 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Canis familiaris (Dog) (Canis lupus familiaris) |
NCBI Taxa ID | 9615 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 506 | PRHLLVMKGAPERIL | acetylation | [1] |
|
Reference | [1] Acid dissociation constant and apparent nucleophilicity of lysine-501 of the alpha-polypeptide of sodium and potassium ion activated adenosinetriphosphatase. Xu KY. Biochemistry. 1989 Aug 22;28(17):6894-9. [ PMID: 2554957] |
Functional Description | This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. |
Sequence Annotation | REGION 80 82 Phosphoinositide-3 kinase binding (By
ACT_SITE 374 374 4-aspartylphosphate intermediate (By
METAL 715 715 Magnesium (By similarity).
METAL 719 719 Magnesium (By similarity).
BINDING 485 485 ATP (By similarity).
MOD_RES 10 10 Phosphotyrosine (By similarity).
MOD_RES 16 16 Phosphoserine; by PKC (By similarity).
MOD_RES 45 45 Phosphoserine (By similarity).
MOD_RES 215 215 Phosphoserine (By similarity).
MOD_RES 217 217 Phosphothreonine (By similarity).
MOD_RES 226 226 Phosphoserine (By similarity).
MOD_RES 258 258 Phosphotyrosine (By similarity).
MOD_RES 450 450 Phosphoserine (By similarity).
MOD_RES 540 540 Phosphotyrosine (By similarity).
MOD_RES 941 941 Phosphoserine; by PKA (By similarity). |
Keyword | ATP-binding; Cell membrane; Complete proteome; Hydrolase; Ion transport; Magnesium; Membrane; Metal-binding; Nucleotide-binding; Phosphoprotein; Potassium; Potassium transport; Reference proteome; Sodium; Sodium transport; Sodium/potassium transport; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1021 AA |
Protein Sequence | MGKGVGRDKY EPAAVSEHGD KKKAKKERDM DELKKEVSMD DHKLSLDELH RKYGTDLSRG 60
LTTARAAEIL ARDGPNALTP PPTTPEWVKF CRQLFGGFSM LLWIGAILCF LAYGIQAATE 120
EEPQNDNLYL GVVLSAVVII TGCFSYYQEA KSSKIMESFK NMVPQQALVI RNGEKMSINA 180
EEVVIGDLVE VKGGDRIPAD LRIISANGCK VDNSSLTGES EPQTRSPDFT NENPLETRNI 240
AFFSTNCVKG TARGIVVYTG DRTVMGRIAT LASGLEGGQT PIAAEIEHFI HIITGVAVFL 300
GVSFFILSLI LEYTWLEAVI FLIGIIVANV PEGLLATVTV CLTLTAKRMA RKNCLVKNLE 360
AVETLGSTST ICSDKTGTLT QNRMTVAHMW FDNQIHEADT TENQSGVSFD KSSATWLALS 420
RIAGLCNRAV FQANQENLPI LKRAVAGDAS ESALLKCIEL CCGSVKEMRD RYAKIVEIPF 480
NSTNKYQLSI HKNPNTSEPR HLLVMKGAPE RILDRCSSIL LHGKEQPLDE ELKDALQNAY 540
LELGGLGERV LGFRHLFLPD EQFPEGFQFD TDDVNFPVEN LCFVGFISMI GPPRAAVPDA 600
VGKCRGAGIK VIMVTGDHPI TAKAIAKGAG IISEGNETVE DIAARLNIPV RQVNPRDAKA 660
CVVHGSDLKD MTSEQLDGIL KYHTEIVFAR TSPQQKLIIV EGCQRQGAIV AVTGDGVNDS 720
PALKKADIGV AMGIVGSDAS KQAADMILLD DNFASIVTGV EEGRLIFDNL KKSIAYTLTS 780
NIPEITPFLI FIIANIPLPL GTVTILCIDL GTDMVPAISL AYEQAESDIM KRQPRNPKTD 840
KLVNERLISM AYGQIGMIQA LGGFFTYFVI LAENGFLPTH LLGLRVDWDD RWINDVEDSY 900
GQQWTYEQRK IVEFTCHTAF FVSIVVVQWA DLVICKTRRN SVFQQGMKNK ILIFGLFEET 960
ALAAFLSYCP GMGVALRMYP LKPTWWFCAF PYSLLIFVYD EVRKLIIRRR PGGWVEKETY 1020
Y 1021 |
Gene Ontology | GO:0016021; C:integral to membrane; ISS:UniProtKB. GO:0042470; C:melanosome; IEA:UniProtKB-SubCell. GO:0005886; C:plasma membrane; ISS:UniProtKB. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0005391; F:sodium:potassium-exchanging ATPase activity; ISS:UniProtKB. GO:0006754; P:ATP biosynthetic process; IEA:InterPro. GO:0002028; P:regulation of sodium ion transport; ISS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |