CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-026416
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 
Protein Synonyms/Alias
 Protein Ddx18 
Gene Name
 Ddx18 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
49DVPEELGKGGKAKKAacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Helicase; Hydrolase; Nucleotide-binding; Reference proteome; RNA-binding. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 674 AA 
Protein Sequence
MSQLQMKLLR KKIEKRNAKL RQRNLKLQEA SDRSLSQPEN GDVPEELGKG GKAKKALKHS 60
VTAGSAEAQS RGVPEETVEN AKVKKSPQKL TILTNGEAAA MPSTDPELKK KKKKKRKIGN 120
DTEPDPKKAK TEEGTEAREE PEGAGEEPEG AGEEPEDGVK EADDSEVPSL PLGVTGAFED 180
TSFASLSNLV NENTLKAIEE MGFKHMTEIQ HKSIRPLLEG RDLLAAAKTG SGKTLAFLIP 240
VIELIVKLKF MPRNGTGVLI LSPTRELAMQ TFGVLKELMT HHVHTYGLIM GGSNRSAEVQ 300
KLLNGINIVV ATPGRLLDHM QNTPGFMYKN LQCLVIDEAD RILDVGFEEE LKQIIKLLPA 360
RRQTMLFSAT QTRKVEDLAR ISLKKEPLYV GVDDDKEVAT VDGLEQGYVV CPSEKRFLLL 420
FTFLKKNRKK KVMVFFSSCM SVKYHYELLN YIDLPVLAIH GKQKQNKRTT TFFQFCNADS 480
GILLCTDVAA RGLDIPEVDW IVQYDPPDDP KEYIHRVGRT ARGLNGRGHA LLILRPEELG 540
FLRYLKQSKV PLNQFDFSWS KVSDIQSQLE KLIEKNYFLH KSAQEAYKSY IRAYDSHSLK 600
QIFNVNNLNL PQVALSFGFK VPPFVDLNVS SHDGKLKKRG GGGGFGYQKT KKVEKSKIFK 660
HISKKPADRR QFSH 674 
Gene Ontology
 GO:0005730; C:nucleolus; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW. 
Interpro
 IPR011545; DNA/RNA_helicase_DEAD/DEAH_N.
 IPR025313; DUF4217.
 IPR014001; Helicase_ATP-bd.
 IPR001650; Helicase_C.
 IPR027417; P-loop_NTPase.
 IPR000629; RNA-helicase_DEAD-box_CS.
 IPR014014; RNA_helicase_DEAD_Q_motif. 
Pfam
 PF00270; DEAD
 PF13959; DUF4217
 PF00271; Helicase_C 
SMART
 SM00487; DEXDc
 SM00490; HELICc 
PROSITE
 PS00039; DEAD_ATP_HELICASE
 PS51192; HELICASE_ATP_BIND_1
 PS51194; HELICASE_CTER
 PS51195; Q_MOTIF 
PRINTS