CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004651
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Nicotinate phosphoribosyltransferase 
Protein Synonyms/Alias
 NAPRTase 
Gene Name
 pncB 
Gene Synonyms/Alias
 b0931; JW0914 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
106TVSNDNGKLDIRLSGacetylation[1]
190EVQETIVKRLQQESWacetylation[1]
293DPVEWGEKAIAHYEKacetylation[1]
300KAIAHYEKLGIDPQSacetylation[1]
350TCDIPQVKPLNIVIKacetylation[1]
381GKTICHDKAFVRALRacetylation[1]
389AFVRALRKAFDLPHIacetylation[1]
397AFDLPHIKKAS****acetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 
Functional Description
 Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP (By similarity). 
Sequence Annotation
  
Keyword
 Complete proteome; Cytoplasm; Direct protein sequencing; Ligase; Pyridine nucleotide biosynthesis; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 400 AA 
Protein Sequence
MTQFASPVLH SLLDTDAYKL HMQQAVFHHY YDVHVAAEFR CRGDDLLGIY ADAIREQVQA 60
MQHLRLQDDE YQWLSALPFF KADYLNWLRE FRFNPEQVTV SNDNGKLDIR LSGPWREVIL 120
WEVPLLAVIS EMVHRYRSPQ ADVAQALDTL ESKLVDFSAL TAGLDMSRFH LMDFGTRRRF 180
SREVQETIVK RLQQESWFVG TSNYDLARRL SLTPMGTQAH EWFQAHQQIS PDLANSQRAA 240
LAAWLEEYPD QLGIALTDCI TMDAFLRDFG VEFASRYQGL RHDSGDPVEW GEKAIAHYEK 300
LGIDPQSKTL VFSDNLDLRK AVELYRHFSS RVQLSFGIGT RLTCDIPQVK PLNIVIKLVE 360
CNGKPVAKLS DSPGKTICHD KAFVRALRKA FDLPHIKKAS 400 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0004516; F:nicotinate phosphoribosyltransferase activity; IEA:EC.
 GO:0004514; F:nicotinate-nucleotide diphosphorylase (carboxylating) activity; IEA:InterPro.
 GO:0009435; P:NAD biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0019357; P:nicotinate nucleotide biosynthetic process; IEA:InterPro. 
Interpro
 IPR006406; Nic_PRibTrfase.
 IPR015977; Nic_PRibTrfase-like.
 IPR007229; Nic_PRibTrfase-rel.
 IPR002638; Quinolinate_PRibosylTrfase_C. 
Pfam
 PF04095; NAPRTase 
SMART
  
PROSITE
  
PRINTS