CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040819
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Kinesin-like protein KIF1A 
Protein Synonyms/Alias
  
Gene Name
 KIF1A 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
201DLMDSGNKARTVAATubiquitination[1]
679QRLDYESKLEALQKQubiquitination[2]
685SKLEALQKQMDSRYYubiquitination[1]
753NAISVELKKKVQFQFubiquitination[3]
977RVAIVSEKGEVKGFLubiquitination[4]
1011VRQSGTAKISFDDQHubiquitination[1, 4]
1140AFSTEPLKNTGRGPPubiquitination[1, 4]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [4] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Microtubule; Motor protein; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1471 AA 
Protein Sequence
MAGASVKVAV RVRPFNSREM SRDSKCIIQM SGSTTTIVNP KQPKETPKSF SFDYSYWSHT 60
SPEDINYASQ KQVYRDIGEE MLQHAFEGYN VCIFAYGQTG AGKSYTMMGK QEKDQQGIIP 120
QLCEDLFSRI NDTTNDNMSY SVEVSYMEIY CERVRDLLNP KNKGNLRVRE HPLLGPYVED 180
LSKLAVTSYN DIQDLMDSGN KARTVAATNM NETSSRSHAV FNIIFTQKRH DAETNITTEK 240
VSKISLVDLA GSERADSTGA KGTRLKEGAN INKSLTTLGK VISALAEMDS GPNKNKKKKK 300
TDFIPYRDSV LTWLLRENLG GNSRTAMVAA LSPADINYDE TLSTLRYADR AKQIRCNAVI 360
NEDPNNKLIR ELKDEVTRLR DLLYAQGLGD ITDTNTVPGG PKLTNALVGM SPSSSLSALS 420
SRAASVSSLH ERILFAPGSE EAIERLKETE KIIAELNETW EEKLRRTEAI RMEREALLAE 480
MGVAMREDGG TLGVFSPKKT PHLVNLNEDP LMSECLLYYI KDGITRVGRE DGERRQDIVL 540
SGHFIKEEHC VFRSDSRGGS EAVVTLEPCE GADTYVNGKK VTEPSILRSG NRIIMGKSHV 600
FRFNHPEQAR QERERTPCAE TPAEPVDWAF AQRELLEKQG IDMKQEMEQR LQELEDQYRR 660
EREEATYLLE QQRLDYESKL EALQKQMDSR YYPEVNEEEE EPEDEVQWTE RECELALWAF 720
RKWKWYQFTS LRDLLWGNAI FLKEANAISV ELKKKVQFQF VLLTDTLYSP LPPDLLPPEA 780
AKDRETRPFP RTIVAVEVQD QKNGATHYWT LEKLRQRLDL MREMYDRAAE VPSSVIEDCD 840
NVVTGGDPFY DRFPWFRLVG SSAISGCNSY PLLNTCMSER MAALTPSPTF SSPDSDATEP 900
AEEQSVGEEE EEEEEEEDEE EEDLEDDVFP EHALCDGRDP FYDRPPLFSL VGRAFVYLSN 960
LLYPVPLVHR VAIVSEKGEV KGFLRVAVQA ISADEEAPDY GSGVRQSGTA KISFDDQHFE 1020
KFQSESCPVV GMSRSGTSQE ELRIVEGQGQ GADVGPSADE VNNNTCSAVP PEGLLLDSSE 1080
KAALDGPLDA ALDHLRLGNT FTFRVTVLQA SSISAEYADI FCQFNFIHRH DEAFSTEPLK 1140
NTGRGPPLGF YHVQNIAVEV TKSFIEYIKS QPIVFEVFGH YQQHPFPPLC KDVLSPLRPS 1200
RRHFPRVMPL SKPVPATKLS TLTRPCPGPC HCKYDLLVYF EICELEANGD YIPAVVDHRG 1260
GMPCMGTFLL HQGIQRRITV TLLHETGSHI RWKEVRELVV GRIRNTPETD ESLIDPNILS 1320
LNILSSGYIH PAQDDRVSLG NDTRTFYQFE AAWDSSMHNS LLLNRVTPYR EKIYMTLSAY 1380
IEMENCTQPA VVTKDFCMVF YSRDAKLPAS RSIRNLFGSG SLRASESNRV TGVYELSLCH 1440
VADAGSPGMQ RRRRRVLDTS VAYVRGEENL A 1471 
Gene Ontology
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0005875; C:microtubule associated complex; IEA:InterPro.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0003777; F:microtubule motor activity; IEA:InterPro.
 GO:0007018; P:microtubule-based movement; IEA:InterPro. 
Interpro
 IPR000253; FHA_dom.
 IPR022140; KIF1B.
 IPR022164; Kinesin-like.
 IPR019821; Kinesin_motor_CS.
 IPR001752; Kinesin_motor_dom.
 IPR027417; P-loop_NTPase.
 IPR008984; SMAD_FHA_domain. 
Pfam
 PF12473; DUF3694
 PF00498; FHA
 PF12423; KIF1B
 PF00225; Kinesin 
SMART
 SM00240; FHA
 SM00129; KISc 
PROSITE
 PS50006; FHA_DOMAIN
 PS00411; KINESIN_MOTOR_DOMAIN1
 PS50067; KINESIN_MOTOR_DOMAIN2 
PRINTS
 PR00380; KINESINHEAVY.