CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006946
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 GTP-binding protein YPT31/YPT8 
Protein Synonyms/Alias
 Rab GTPase YPT31 
Gene Name
 YPT31 
Gene Synonyms/Alias
 YPT8; YER031C 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
26IGDSGVGKSNLLSRFubiquitination[1]
35NLLSRFTKNEFNMDSubiquitination[1]
63EIDGKRIKAQIWDTAubiquitination[1]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, VillĂ©n J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301
Functional Description
 Required for protein transport in the secretory pathway. Probably involved in regulation of secretory vesicle formation at the trans-Golgi compartment. Plays a role in autophagy. 
Sequence Annotation
 NP_BIND 20 27 GTP (By similarity).
 NP_BIND 68 72 GTP (By similarity).
 NP_BIND 126 129 GTP (By similarity).
 MOTIF 42 50 Effector region (Probable).
 MOD_RES 2 2 N-acetylserine.
 LIPID 222 222 S-geranylgeranyl cysteine (By
 LIPID 223 223 S-geranylgeranyl cysteine (By  
Keyword
 3D-structure; Acetylation; Autophagy; Complete proteome; Direct protein sequencing; Golgi apparatus; GTP-binding; Lipoprotein; Membrane; Nucleotide-binding; Prenylation; Protein transport; Reference proteome; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 223 AA 
Protein Sequence
MSSEDYGYDY DLLFKIVLIG DSGVGKSNLL SRFTKNEFNM DSKSTIGVEF ATRTLEIDGK 60
RIKAQIWDTA GQERYRAITS AYYRGAVGAL IVYDISKSSS YENCNHWLSE LRENADDNVA 120
VGLIGNKSDL AHLRAVPTEE SKTFAQENQL LFTETSALNS ENVDKAFEEL INTIYQKVSK 180
HQMDLGDSSA NGNANGASAP NGPTISLTPT PNENKKANGN NCC 223 
Gene Ontology
 GO:0005768; C:endosome; IDA:SGD.
 GO:0005794; C:Golgi apparatus; IDA:SGD.
 GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
 GO:0005741; C:mitochondrial outer membrane; IDA:SGD.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0003924; F:GTPase activity; IDA:SGD.
 GO:0006914; P:autophagy; IEA:UniProtKB-KW.
 GO:0034498; P:early endosome to Golgi transport; IGI:SGD.
 GO:0006887; P:exocytosis; IMP:SGD.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. 
Interpro
 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR001806; Small_GTPase.
 IPR003579; Small_GTPase_Rab_type. 
Pfam
 PF00071; Ras 
SMART
 SM00175; RAB 
PROSITE
 PS51419; RAB 
PRINTS
 PR00449; RASTRNSFRMNG.