UniProt Accession

 BSD2_YEAST; P38356; D6VQT5 

Genbank Protein ID

 L33783; X76053; Z36159; BK006936 

Genbank Nucleotide ID

 AAA65065.1; CAA53653.1; CAA85255.1; DAA07405.1 

Protein Name

 Metal homeostatis protein BSD2 

Protein Synonyms/Alias

 Bypass SOD defects protein 2 

Gene Name

 BSD2 

Gene Synonyms/Alias

 YBR290W; YBR2037 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
312	QVKKLEKKYLNQSQN	ubiquitination	[1, 2, 3, 4, 5]

Reference

 [1] A proteomics approach to understanding protein ubiquitination.
 Peng J, Schwartz D, Elias JE, Thoreen CC, Cheng D, Marsischky G, Roelofs J, Finley D, Gygi SP.
 Nat Biotechnol. 2003 Aug;21(8):921-6. [PMID: 12872131]
 [2] Computational identification of ubiquitylation sites from protein sequences.
 Tung CW, Ho SY.
 BMC Bioinformatics. 2008 Jul 15;9:310. [PMID: 18625080]
 [3] Identification, analysis, and prediction of protein ubiquitination sites.
 Radivojac P, Vacic V, Haynes C, Cocklin RR, Mohan A, Heyen JW, Goebl MG, Iakoucheva LM.
 Proteins. 2010 Feb 1;78(2):365-80. [PMID: 19722269]
 [4] Sites of ubiquitin attachment in Saccharomyces cerevisiae.
 Starita LM, Lo RS, Eng JK, von Haller PD, Fields S.
 Proteomics. 2012 Jan;12(2):236-40. [PMID: 22106047]
 [5] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Required for homeostasis of heavy metal ions such as cadmium, cobalt and copper. Controls metal ion transport and prevents metal hyperaccumulation by negatively regulating the SMF1 and SMF2 metal transport systems. Under manganese-replete conditions facilitates trafficking of SMF1 and SMF2 metal transporters to the vacuole where they are degraded. 

Sequence Annotation

 CROSSLNK 312 312 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 Complete proteome; Endoplasmic reticulum; Isopeptide bond; Membrane; Reference proteome; Stress response; Transmembrane; Transmembrane helix; Transport; Ubl conjugation; Vacuole. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 321 AA 

Protein Sequence

Gene Ontology

 GO:0005783; C:endoplasmic reticulum; IDA:SGD.
 GO:0000329; C:fungal-type vacuole membrane; IDA:SGD.
 GO:0016021; C:integral to membrane; ISM:SGD.
 GO:0030001; P:metal ion transport; IMP:SGD.
 GO:0006623; P:protein targeting to vacuole; IMP:SGD.
 GO:0006950; P:response to stress; IEA:UniProtKB-KW.
 GO:0006511; P:ubiquitin-dependent protein catabolic process; IMP:SGD. 

Interpro

 IPR019325; NEDD4/BSD2. 

Pfam

 PF10176; DUF2370 

SMART

  

PROSITE

  

PRINTS