CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-036908
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Inhibitor of Bruton tyrosine kinase 
Protein Synonyms/Alias
  
Gene Name
 IBTK 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
655KPRIHLNKNPEEYQGubiquitination[1]
687KSAFEVYKSNQAQTVubiquitination[1, 2]
1198DFLLEEKKSVTSHSSubiquitination[1]
1335LAVPMWNKHGC****ubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
  
Sequence Annotation
  
Keyword
 ANK repeat; Complete proteome; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1338 AA 
Protein Sequence
MSSPMPDCTS KCRSLKHALD VLSVVTKGSE NQIKAFLSSH CYNAATIKDV FGRNALHLVS 60
SCGKKGVLDW LIQKGVDLLV KDKESGWTAL HRSIFYGHID CVWSLLKHGV SLYIQDKEGL 120
SALDLVMKDR PTHVVFKNTD PTDVYTWGDN TNFTLGHGSQ NSKHHPELVD LFSRSGIYIK 180
QVVLCKFHSV FLSQKGQVYT CGHGPGGRLG HGDEQTCLVP RLVEGLNGHN CSQVAAAKDH 240
TVVLTEDGCV YTFGLNIFHQ LGIIPPPSSC NVPRQIQAKY LKGRTIIGVA AGRFHTVLWT 300
REAVYTMGLN GGQLGCLLDP NGEKCVTAPR QVSALHHKDI ALSLVAASDG ATVCVTTRGD 360
IYLLADYQCK KMASKQLNLK KVLVSGGHME YKVDPEHLKE NGGQKICILA MDGAGRVFCW 420
RSVNSSLKQC RWAYPRQVFI SDIALNRNEI LFVTQDGEGF RGRWFEEKRK SSEKKEILSN 480
LHNSSSDVSY VSDINSVYER IRLEKLTFAH RAVSVSTDPS GCNFAILQSD PKTSLYEIPA 540
VSSSSFFEEF GKLLREADEM DSIHDVTFQV GNRLFPAHKY ILAVHSDFFQ KLFLSDGNTS 600
EFTDIYQKDE DSAGCHLFVV EKVHPDMFEY LLQFIYTDTC DFLTHGFKPR IHLNKNPEEY 660
QGTLNSHLNK VNFHEDDNQK SAFEVYKSNQ AQTVSERQKS KPKSCKKGKN IREDDPVRML 720
QTVAKKFDFS NLSSRLDGVR FENEKINVIA KNTGNKLKLS QKKCSFLCDV TMKSVDGKEF 780
PCHKCVLCAR LEYFHSMLSS SWIEASSCAA LEMPIHSDIL KVILDYLYTD EAVVIKESQN 840
VDFICSVLVV ADQLLITRLK EICEVALTEK LTLKNAAMLL EFAAMYSAKQ LKLSCLQFIG 900
LNMAALLEAR SLDVLSDGVL KDLSEFYRKM IPAMDRRVIT PYQDGPDISY LEVEDGDIFL 960
KEEINMEQNH SETMFKKAKT KAKKKPRKRS DSSGGYNLSD IIQSPSSTEL LTSDSEGSYA 1020
GVGSPRDLQS PDFTTGFHSD KIEAKVKPYV NGTSPVYSRE DLKPWEKSPI LKISAPQPIP 1080
SNRIDTTSSA SWVAGSFSPV SPPVVDLRTI MEIEESRQKC GATPKSHLGK TVSHGVKLSQ 1140
KQRKMIALTT KENNSGMNSM ETVLFTPSKA PKPVNAWASS LHSVSSKSFR DFLLEEKKSV 1200
TSHSSGDHVK KVSFKGIENS QAPKIVRCST HGTPGPEGNH ISDLPLLDSP NPWLSSSVTA 1260
PSMVAPVTFA SIVEEELQQE AALIRSREKP LALIQIEEHA IQDLLVFYEA FGNPEEFVIV 1320
ERTPQGPLAV PMWNKHGC 1338 
Gene Ontology
 GO:0005634; C:nucleus; IDA:HPA. 
Interpro
 IPR002110; Ankyrin_rpt.
 IPR020683; Ankyrin_rpt-contain_dom.
 IPR000210; BTB/POZ-like.
 IPR011333; BTB/POZ_fold.
 IPR013069; BTB_POZ.
 IPR009091; RCC1/BLIP-II.
 IPR000408; Reg_chr_condens. 
Pfam
 PF12796; Ank_2
 PF00651; BTB
 PF00415; RCC1 
SMART
 SM00248; ANK
 SM00225; BTB 
PROSITE
 PS50297; ANK_REP_REGION
 PS50088; ANK_REPEAT
 PS50097; BTB
 PS50012; RCC1_3 
PRINTS