UniProt Accession

 TF2B_MOUSE; P62915; P29053 

Genbank Protein ID

 BC016637 

Genbank Nucleotide ID

 AAH16637.1 

Protein Name

 Transcription initiation factor IIB 

Protein Synonyms/Alias

 General transcription factor TFIIB; RNA polymerase II alpha initiation factor 

Gene Name

 Gtf2b 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
119	RAMMNAFKEITTMAD	ubiquitination	[1]
178	EGVPRTFKEICAVSR	acetylation	[2]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

 General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II (By similarity). 

Sequence Annotation

 REPEAT 124 200 1.
 REPEAT 218 294 2.
 ZN_FING 11 42 TFIIB-type.
 METAL 15 15 Zinc (By similarity).
 METAL 18 18 Zinc (By similarity).
 METAL 34 34 Zinc (By similarity).
 METAL 37 37 Zinc (By similarity).
 MOD_RES 76 76 Phosphoserine (By similarity).  

Keyword

 Complete proteome; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 316 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IDA:MGI.
 GO:0001047; F:core promoter binding; IDA:MGI.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006352; P:DNA-dependent transcription, initiation; IEA:InterPro.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR013763; Cyclin-like.
 IPR000812; TFIIB.
 IPR023486; TFIIB_CS.
 IPR013150; TFIIB_cyclin.
 IPR013137; Znf_TFIIB. 

Pfam

 PF08271; TF_Zn_Ribbon
 PF00382; TFIIB 

SMART

 SM00385; CYCLIN 

PROSITE

 PS00782; TFIIB
 PS51134; ZF_TFIIB 

PRINTS

 PR00685; TIFACTORIIB.